DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and metro

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	191/654 - (29%)
Similarity:	309/654 - (47%)	Gaps:	134/654 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AAFRNSTDLSDHDEI-FLKGLLRSNSNTPHKEL--MLN-PTEPQPV---PLFLPAHLNNKPICDD 93
            :..:.|.:||:..|| |||.||.|      |||  ::| .|:...|   ....|....:..:..:
  Fly    21 STLKESENLSNDQEIDFLKALLES------KELNALVNVHTKVAKVGRDDRLAPVLSTSAQVLYE 79

  Fly    94 IIRKFSPSRRL--ESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGG 156
            ::.:.|....|  :.:|...||...|.:.||.|||.|                     :|:....
  Fly    80 VLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAI---------------------AQKDFYP 123

  Fly   157 YLFTEDVLNTKMPV------ETIKMVGLRRDPSKPL----------GLTVELDEFK-QLVVARIL 204
            :|       .:.||      ||||:|.|.:. ::||          |.|::.||.. ::::|||:
  Fly   124 HL-------PEAPVEMDEDEETIKIVQLVKS-NEPLTGAQSTEPIVGATIKTDEESGKIIIARIM 180

  Fly   205 AGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSG 267
            .||..|:..::||||.::|||...|  :||.::...:..::..:|.|:.| .|.:         |
  Fly   181 HGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVP-ADNK---------G 235

  Fly   268 GQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKN 332
            .|            ::....:||.|.|||..|..:||::.||.|:.||:|.|:...|..||||:.
  Fly   236 AQ------------RESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARK 288

  Fly   333 ITAESDKIGLIPSQELEERRKAFVAPE---ADYVHKIGICGTRIS-------------------K 375
            ....|.:.|||||:.|:|||......:   .|...|.|.|.:..:                   .
  Fly   289 EHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQP 353

  Fly   376 RKRKTMYRSVANCEFDKAELLLYEEVTRMPP----FRRKTLVLIGVSGVGRRTLKNRLINSDVDK 436
            :.:|.||....|.:||:.::..||||.::.|    ||  .:||||..||||..|:.|||..|.:|
  Fly   354 KTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFR--PIVLIGAPGVGRNELRRRLIARDPEK 416

  Fly   437 FGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGR 501
            |.:.:|:|:||.|..|..|..|.|:.||:|:..:...:|:|:||:.|:||||..:|:|.::|:|.
  Fly   417 FRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGC 481

  Fly   502 MCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRR 566
            :|:|.....|:|.|..:| |.||:|.|..|.::.||....:.||..     :||..::..|:..
  Fly   482 VCVLSPHYQAIKTLRTAQ-LKPFLIHVKPPELDILKATRTEARAKS-----TFDEANARSFTDE- 539

  Fly   567 ARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVP 631
                       |.:|::.:.|...|:   |..:||:.:||.:....|.|:|:.:.::.:|..|.|
  Fly   540 -----------EFEDMIKSAERIDFL---YGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAP 590

  Fly   632 VNWI 635
            ..|:
  Fly   591 SMWV 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	9/22 (41%)
		PDZ_signaling	173..250	CDD:238492	27/89 (30%)
		SH3_MPP	287..347	CDD:212796	27/59 (46%)
		Guanylate_kin	408..622	CDD:279019	72/213 (34%)
		GuKc	418..622	CDD:214504	67/203 (33%)
metro	NP_610642.2	L27	17..68	CDD:197794	17/52 (33%)
		L27	75..127	CDD:197794	14/79 (18%)
		PDZ_signaling	139..229	CDD:238492	28/90 (31%)
		SH3_MPP	243..302	CDD:212796	26/58 (45%)
		Guanylate_kin	390..575	CDD:279019	70/207 (34%)
		GuKc	399..580	CDD:214504	67/201 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840