DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and magu-2

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001355433.1	Gene:	magu-2 / 3565703	WormBaseID:	WBGene00006467	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	695	Identity:	177/695 - (25%)
Similarity:	304/695 - (43%)	Gaps:	182/695 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 DHDEIFLKGLLRSNSNTPHKELMLNP--TEPQPVPLFLPAHLNNKPICDDIIRKFSPSRR----- 103
            :.:..||:..||.:.........::|  .||..|..|.      .|:.:   .:.:|||:
Worm   209 EQENTFLRSSLRKSKKLQALARNVDPLTNEPMKVTSFA------NPLAE---VEETPSRKTENGA 264

  Fly   104 ---------LESRE----------------------LAKLLAQPHFR----ALLR---AHDEIGA 130
                     |||.|                      :|..|:....|    |:||   |...|.|
Worm   265 TRITVGEEVLESSEVLIDEENKDSRQLDEVIISVERIASKLSSMQGRESDVAMLRDFFAAPPIQA 329

  Fly   131 LYEQRLKAAG--GSTSQLEIASQRQTGGYLFTEDVLNTKMPV----------------------- 170
            ..||.:|..|  |:||.   .....:||    :....|..|:
Worm   330 AIEQTVKQNGKCGTTSS---GIGTDSGG----DSSSCTSSPIPPVIMNGNGKSERCPSTSSSSSV 387

  Fly   171 -----ETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVR 230
                 ..:|:|.:.:|....||.||. :|..:::|.|::.||:::|.::...||.:||:||:.::
Worm   388 SPRNAPNVKVVEVVKDEDSYLGATVR-NENNKIIVGRVVKGGIVEKMNLFQEGDELLELNGSSLK 451

  Fly   231 TPDELQV-EVSRAKENL----TLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRA 290
            ..   || |:.....||    |..:.|..:::.:....|.:      |.:.:.::.:.:. ::||
Worm   452 GK---QVNEICDILRNLSGPITFVVAPKEEQDTEQPTDTAT------NTVTAKKSQQHVQ-HLRA 506

  Fly   291 LFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQA----KNITAESDKIGLIPS------ 345
            ||.|:|.:|..:||:::.:.|:.||||.::|.||.|||||    ::|  :....|||||
Worm   507 LFDYDPEDDVYVPCKELAMKFQRGDILHVLNTKDDNWWQAYRDGEDI--QHSLAGLIPSSSFRQQ 569

  Fly   346 ---------QELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKA-----ELL 396
                     :|.|::||.              |.   .|:|:|...:..|:.|...|     :.|
Worm   570 VVLYADEVEREQEQKRKE--------------CK---GKKKKKLEVKKGADEENLPAIGVYSDFL 617

  Fly   397 LYEEVTRMPP--FRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYW 459
            .||||....|  ..|:.:||.|..|||...|::||:.||.......:|:|||..:..|.||..|.
Worm   618 TYEEVVLELPKATHRRPIVLCGAEGVGCLKLRDRLLESDRITLACPVPYTSRTPKEGEFNGVHYH 682

  Fly   460 FMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPF 524
            |:.:::..|..::.:|:|:||:....|||..:.:.:||..|:.|::.....:|..: .|.::.|:
Worm   683 FVSKQKFHEDAKSGKFVEFGEYQKFWYGTAKKDVVNVIERGKTCVMTLKAESLGAI-RSPDIQPY 746

  Fly   525 VIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEES 589
            :||:|||.:                            :..||.|.:|....: :||:|.|.:.:|
Worm   747 IIFIAAPSL----------------------------YILRRQREVEGTFGV-KDDELKAILTQS 782

  Fly   590 SFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNW 634
            ..:::||...||.:|||.||:::||::.:.|.:::.|..|||..|
Worm   783 KSIEQKYGHLFDGIIVNIDFEKSFRELKQILMKVNTEPMWVPATW 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	10/51 (20%)
		PDZ_signaling	173..250	CDD:238492	25/81 (31%)
		SH3_MPP	287..347	CDD:212796	28/78 (36%)
		Guanylate_kin	408..622	CDD:279019	62/213 (29%)
		GuKc	418..622	CDD:214504	58/203 (29%)
magu-2	NP_001355433.1	PDZ	<59..107	CDD:238080
		PDZ_signaling	408..474	CDD:238492	22/69 (32%)
		SH3_MPP5	503..565	CDD:212969	28/63 (44%)
		GuKc	642..817	CDD:214504	58/204 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810