DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Dlg5

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster

Alignment Length:	622	Identity:	141/622 - (22%)
Similarity:	236/622 - (37%)	Gaps:	148/622 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SNSNTPHKELMLNPTEPQPVPLF-LPAHLNNKPICDDIIRKFSPSRRLESRELAKL----LAQPH 117
            |.|.||..    :|..|....|| ||            ::..:||.|..||  |.|    :....
  Fly  1395 SGSPTPRN----SPRPPARNSLFPLP------------MQPQAPSTRPGSR--APLSHQSIKDQS 1441

  Fly   118 FRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNT------KMPVETIKMV 176
            |...|....:|.:..:....||   |:....||...|   ::.|:...:      .:|.||::.|
  Fly  1442 FTDSLENQSDISSSQDMPSSAA---TTTTTTASATST---VYDEEPKPSLPPPPASVPAETLRYV 1500

  Fly   177 GLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVR--TPDELQVEV 239
            .|..|.||.||:.:.......:.|..:..|...| .:.:..||.|||.||..:.  |.::...|:
  Fly  1501 TLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSD-HAGIRKGDQILEYNGVDLSGVTAEQAANEI 1564

  Fly   240 SRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALF--TYNPSEDSLL 302
            |:..:.:|:.        :::..:|:.  |:|.      |.|...  |:|..|  |...:||.
  Fly  1565 SKLTDTVTML--------VQNKLHTLK--QIKD------EPGDSF--YIRVGFDRTGELNEDD-- 1609

  Fly   303 PCRDIGLPFKSGDILQIIN-VKDPNW--WQAKNITA--ESDKIGLIPSQ-ELEERRKAFVAPEAD 361
                  |.|...::|.:.| |.:..:  |:|..:.|  ...:.|:|||| ::||..::....:.|
  Fly  1610 ------LRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGEVVDCD 1668

  Fly   362 Y-VHKIGICGTRISKRKRKTMYRSVAN-----CEFDKAEL---------------LLYEEVTRM- 404
            . ..:.|....|.|..:||...||.:.     ..|...:|               |.|:.|..:
  Fly  1669 TGTARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLD 1733

  Fly   405 PPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMD--REEME 467
            .|.||..|::    |.....|..|| ..|......:...|:               ||  :|.||
  Fly  1734 SPIRRPVLII----GPLSECLMVRL-TIDFSNLFKLCEVTA---------------MDCSQEAME 1778

  Fly   468 EAVRNNEFLEYGEHNGNLYGTHLQSIKDVI-NSGRMCILDCAPNALKILHNSQELMPFVIFVAAP 531
            |.::.|.|::|.........|.:::|.:.. |..|.||||.:.:|::.|...| :.|.|:.:...
  Fly  1779 EGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQ-IYPIVLLLRFK 1842

  Fly   532 GMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKY 596
            ..:|::.|          |:...|     :.|::.|:.:...|...|.|               |
  Fly  1843 SAKQIRDI----------RDFGTD-----KISAKAAKEMYERAMKLETD---------------Y 1877

  Fly   597 EKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVN 633
            ::|...||..........|:.:.:|:...:..||||:
  Fly  1878 KQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVPVS 1914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	6/26 (23%)
		PDZ_signaling	173..250	CDD:238492	21/78 (27%)
		SH3_MPP	287..347	CDD:212796	19/67 (28%)
		Guanylate_kin	408..622	CDD:279019	45/216 (21%)
		GuKc	418..622	CDD:214504	42/206 (20%)
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492	21/87 (24%)
		SH3_DLG5	1594..1657	CDD:212794	19/70 (27%)
		Guanylate_kin	1737..1904	CDD:279019	46/217 (21%)
		NK	<1773..1905	CDD:302627	35/162 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810