Protein Alignment vari and mpp1

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_999857.1
• Gene: mpp1 / 325542
• ZFINID: ZDB-GENE-031113-4
• Length: 468
• Species: Danio rerio
• Alignment Length: 587
• Identity: 186/587 - (31%)
• Similarity: 290/587 - (49%)
• Gaps: 127/587 - (21%)

  Fly    56 LRSNSNTPHKEL-MLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFR 119
            |.||.|.|...| .:|........|:|...|.|||..:                          :
Zfish     3 LNSNKNEPAVILERVNSARTALSDLYLEQLLQNKPKSE--------------------------K 41

  Fly   120 ALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSK 184
            |.::.::..|    |.:.:.|             :.|::...|.  |:|     :.|...::||:
Zfish    42 AAMQTYECKG----QEVFSNG-------------SAGHMNGRDA--TRM-----REVAFEKNPSE 82

  Fly   185 PLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLT 247
            |||:|::|:|.::..|||||.||:|.:|..||.||.|.|:||..|  ::.|:||..:......:|
Zfish    83 PLGVTLKLNEKQRCTVARILHGGMIHRQGSLHEGDEIAEINGKSVSNQSVDQLQKILKDTNGVVT 147

  Fly   248 LKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTC--YMRALFTYNPSEDSLLPCRDIGLP 310
            |||..|                         :..:.:.|  ||||.|.|:|::|.|:||::.||.
Zfish   148 LKIISN-------------------------QQSRPMACEMYMRAQFDYDPAKDELIPCKEAGLK 187

  Fly   311 FKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIG-ICGTRIS 374
            |::|||:.|||.|||||||.|..::.:|..|||||.||:|.|   ||.::....:.| .|.....
Zfish   188 FQTGDIIHIINKKDPNWWQGKVDSSSTDFAGLIPSPELQEWR---VASKSKATREAGQSCSPFGK 249

  Fly   375 KRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGA 439
            |:|.|..|.:..:..||:.:::.||||.|:|.|.||||||||..||||..:||.|::...:||..
Zfish   250 KKKCKDKYLAKHSSIFDQLDVISYEEVVRLPAFNRKTLVLIGAHGVGRSLIKNSLLSKYPEKFAY 314

  Fly   440 VIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCI 504
            ..|||:||::..||||..|:|:..:||.:.:..|:.||||.:.|:::||.:::|..:...|::.:
Zfish   315 PAPHTTRPQKKDEENGKEYYFISNDEMTKGIVGNKLLEYGSYQGHMFGTKIETIHKIHEQGKIAV 379

  Fly   505 LDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRART 569
            ||..|..||:|..: |..|.|||:|...             ||:              .|...:.
Zfish   380 LDVEPQTLKVLRTA-EFAPLVIFIAPTN-------------TGN--------------QSEAVQN 416

  Fly   570 LESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNW 634
            ::.     |.|.|:|.          :..:||.::||.|.||:.:.|.:.:::.|...||||::|
Zfish   417 IQK-----ESDSLLAA----------HRHFFDEILVNNDVDESVKGVEDAIERASSSPQWVPISW 466

  Fly   635 IY 636
            :|
Zfish   467 VY 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	1/22 (5%)
		PDZ_signaling	173..250	CDD:238492	32/78 (41%)
		SH3_MPP	287..347	CDD:212796	34/59 (58%)
		Guanylate_kin	408..622	CDD:279019	67/213 (31%)
		GuKc	418..622	CDD:214504	59/203 (29%)
mpp1	NP_999857.1	PDZ	73..151	CDD:278991	33/77 (43%)
		SH3_MPP1	164..225	CDD:213013	34/60 (57%)
		Guanylate_kin	284..453	CDD:279019	67/211 (32%)
		GuKc	293..453	CDD:214504	59/202 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850