Protein Alignment vari and Card10

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_038935185.1
• Gene: Card10 / 315120
• RGDID: 1304949
• Length: 1109
• Species: Rattus norvegicus
• Alignment Length: 651
• Identity: 114/651 - (17%)
• Similarity: 215/651 - (33%)
• Gaps: 222/651 - (34%)

  Fly     5 SARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKEL-- 67
            :|.|||::|:...|..|:.: .:..|  |::||.:...|.::.||....|   |.|......|
  Rat    20 TAPSRRRSRRPNTEPGAQGS-CSARD--SEDAAMQGRADAAEADEEAGAG---SGSEAEEDALWE 78

  Fly    68 -----------MLNPTEPQP--------------------------------------------- 76
                       .|||.:..|
  Rat    79 RIEGVRHRLTRALNPAKLTPYLRQCRVLDEQDEEEVLSTYRFPCRANRTGRLIDILRCRGKRGFE 143

  Fly    77 -----VPLFLPAHL----NNKPI--CDDIIRKFSPS----------RRLESRELAKLLAQPHFRA 120
                 :..:.|.|.    ..:|.  |..|:.:..|.          |||.....::|..:...:|
  Rat   144 AFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLHREQQLQA 208

  Fly   121 LLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKP 185
            ..||.:|..|..||||:....:..:.:...:....|.|   ::|..|   :...|:.:|
  Rat   209 RGRALEEERAGLEQRLREQQAAQERCQRLREDWEAGSL---ELLRLK---DENYMIAMR------ 261

  Fly   186 LGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKI 250
               ..:|.|.|              ..::|...|:.|.|        |:|:::|||.:|...|
  Rat   262 ---LAQLSEEK--------------NSAVLRSRDLQLAV--------DQLKLKVSRLEEECAL-- 299

  Fly   251 GPNVDEEIKSGRYTVSGGQVKQ---NGIASLE----TGKKLTCYMRALFTYNPSEDSLLPCRDIG 308
                   ::.||....|.:.|:   :|:..|.    ..::||..::.|      ::.|.  :::.
  Rat   300 -------LRRGRGPPPGAEEKEKEPDGVDLLSELRAENQRLTASLQEL------QEGLQ--QEMS 349

  Fly   309 LPFKSGDILQIINVKDPNWWQAKNITAE-SDKIGLIPS--QELEERRKAFVAPEAD--------- 361
            .|..:|....::::.:.:|.:|::...| ..|:..:..  |..||.|..::....|
  Rat   350 RPGAAGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDKYLQEMEDLRLKHRTLL 414

  Fly   362 -----YVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVG 421
                 |.|::.....::.:.:::   |..|....|:.:|...:.:.....:|::.
  Rat   415 KDCDLYKHRMATVLAQLEEIEKE---RDQAIQSRDRIQLQYSQSLIEKDQYRKQV---------- 466

  Fly   422 RRTLKNRLINSDVDKFGAVIPHTSRPKRALE----------------------ENGSSYWFMDRE 464
                  |.:.::.|:....:......|..||                      .|.||.|.:
  Rat   467 ------RGLEAERDELLTTVTSLEGTKAMLEAQLQRTQGGSSLKACASSHSLCSNLSSTWSL--- 522

  Fly   465 EMEEAVRNNEF---LEYGEHNGNLYGTHLQSIKDVINS----GRMCILDCAPNALKILHNSQELM 522
                    :||   |...|..|...|:...:.::..:|    .|:.||...|:|..||...:|..
  Rat   523 --------SEFPSPLGGPEATGETGGSEPHTSEEATDSEKEINRLSILPFPPSAGSILRRQREED 579

  Fly   523 P 523
            |
  Rat   580 P 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	4/22 (18%)
		PDZ_signaling	173..250	CDD:238492	16/76 (21%)
		SH3_MPP	287..347	CDD:212796	8/62 (13%)
		Guanylate_kin	408..622	CDD:279019	26/145 (18%)
		GuKc	418..622	CDD:214504	25/135 (19%)
Card10	XP_038935185.1	CARD_CARD10_CARMA3	76..161	CDD:260069	7/84 (8%)
		Smc	<196..>499	CDD:224117	63/375 (17%)
		SH3	784..849	CDD:418401

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900