DRSC/TRiP Functional Genomics Resources

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Protein Alignment vari and Pals1

DIOPT Version :10

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_001101504.1 Gene:Pals1 / 314259 RGDID:1308071 Length:675 Species:Rattus norvegicus


Alignment Length:594 Identity:181/594 - (30%)
Similarity:300/594 - (50%) Gaps:103/594 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 NSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLR 123
            |:.|.|    :|...| |.||.    .|.:.:..::.....|..:.|.:||..||..||.:|||.
  Rat   167 NAVTVH----MNKASP-PFPLI----ANVQDLVQEVQTVLKPVHQKEGQELTALLNAPHIQALLL 222

  Fly   124 AHDEIGALYEQRLKAAGGSTSQLE-IASQR------QTGGYLFTEDVLNTKMPVETIKMVGLRRD 181
            |||::.   ||.:        ||| |..:|      ..||              ||:|:|.:.:.
  Rat   223 AHDKVA---EQEM--------QLEPITDERVYESIGHYGG--------------ETVKIVRIEKA 262

  Fly   182 PSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQV--EVSRAKE 244
            ...|||.||. :|...::::||:.||..:|..:||.||.:||:||..:|..|..:|  .:|....
  Rat   263 RDIPLGATVR-NEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHG 326

  Fly   245 NLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGL 309
            .||..:.|:  ::||.                  ...|:...:::|.|.|:||:|..:|||::||
  Rat   327 TLTFVLIPS--QQIKP------------------PPAKETVIHVKAHFDYDPSDDPYVPCRELGL 371

  Fly   310 PFKSGDILQIINVKDPNWWQAKNITAESDK--IGLIPSQELEERRKAF--VAPEADYVHKIG--I 368
            .|:.||||.:|:.:|||||||.....|.::  .||:|.:..:::|:|.  ...|.....|.|  .
  Rat   372 SFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLW 436

  Fly   369 CGTRISKRKRKTMYRSVANCEFDKAELLLYEEVT--RMPPFRRKTLVLIGVSGVGRRTLKNRLIN 431
            |..:..|:::|.:|.:..|.::|..|:|.|||::  ..|..|::.::|||....|:..|:.||:|
  Rat   437 CAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMN 501

  Fly   432 SDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDV 496
            .:.|:|.:.:|||:|.:|..|..|..|.|:.|:..|..:...:|:|:||...|||||.:.|::.|
  Rat   502 KEKDRFASAVPHTTRNRRDHEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQV 566

  Fly   497 INSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIR 561
            ||||::|:|.....:||.|.|| :|.|::||:|.|..|:|:.:.|..   |.|.           
  Rat   567 INSGKICLLSLRAQSLKTLRNS-DLKPYIIFIAPPSQERLRALLAKE---GKNP----------- 616

  Fly   562 FSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHE 626
                            :.::|...:|::..:::....|||..|||.|.|:.:::::..::::..|
  Rat   617 ----------------KPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTE 665

  Fly   627 EQWVPVNWI 635
            .||||..|:
  Rat   666 PQWVPSTWL 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:460717 13/22 (59%)
PDZ_MPP6-MPP2-like 174..252 CDD:467268 27/79 (34%)
SH3_MPP 287..347 CDD:212796 28/61 (46%)
Guanylate_kin 408..622 CDD:395500 65/213 (31%)
Pals1NP_001101504.1 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2 1..345 64/232 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2 21..140
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..79
L27_N 123..170 CDD:462666 1/2 (50%)
Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2 181..243 24/76 (32%)
L27 189..237 CDD:197794 19/58 (33%)
PDZ_MPP5-like 255..334 CDD:467259 27/79 (34%)
SH3_MPP5 349..411 CDD:212969 28/61 (46%)
GuKc 491..661 CDD:214504 61/200 (31%)
Blue background indicates that the domain is not in the aligned region.

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