DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Mpp7

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_017456050.1	Gene:	Mpp7 / 307035	RGDID:	1305675	Length:	601	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	190/617 - (30%)
Similarity:	302/617 - (48%)	Gaps:	137/617 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PVPLF---------LPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGAL 131
            |||:.         |...|.|||          |:.  |.|||.|||::|:.:|||..||.:
  Rat    65 PVPILHGAAALADDLADELQNKP----------PNS--EIRELLKLLSKPNVKALLSVHDTV--- 114

  Fly   132 YEQRLKAAGGSTSQLEIASQRQTGGYL--FTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDE 194
                              :|:.....|  ..:|:.:.:..|:.|::|..|    :|||.|::.||
  Rat   115 ------------------AQKSYDPVLPPMPDDIDDEEDSVKIIRLVKNR----EPLGATIKKDE 157

  Fly   195 -FKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDE 256
             ...:.||||:.||..|:..::||||.:.||||.||  :.|:|:...:|:::..:|.||.|:..|
  Rat   158 QTGAITVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILSQSQGAITFKIIPSTKE 222

  Fly   257 EIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIIN 321
            ||.|                  :.||   .:::|||.|:|.||..:||::.||.|:.||||||::
  Rat   223 EIPS------------------KEGK---IFIKALFDYDPKEDKAIPCKEAGLSFRKGDILQIMS 266

  Fly   322 VKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPE-----------ADYVHKIG-------- 367
            ..|..|||||:....:.:.|||||:..:|||.|...||           ..|...:.
  Rat   267 QDDATWWQAKHEGDTNPRAGLIPSKHFQERRLALRRPEIVVQPLKLSNRKSYEETVECEEIKEDA 331

  Fly   368 ----------ICGTRIS-------KRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKT---- 411
                      |.|.|.|       |:..|:||....:.::|.|::..|||||   |:||:|
  Rat   332 GHDGNNSGPYIAGFRRSFRLSRKDKKTNKSMYECKKSEQYDTADVPTYEEVT---PYRRQTHDKY 393

  Fly   412 --LVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNE 474
              :||:|..|||...||.:|:.||...:|..:|||:|.:|:.|.:|..|.|:.:...|..|:||:
  Rat   394 RLVVLVGPVGVGLNELKRKLLMSDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNK 458

  Fly   475 FLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTI 539
            |:||||:..|.|||.:.|::.|:...::|:||..|:.:|.| .:.|..|:|||:..|.:|:|
  Rat   459 FIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHL-RTLEFKPYVIFIKPPSIERL--- 519

  Fly   540 YADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVI 604
                |.|..|..:...|..            :..|..:.::|....::.:..::.:|...||.:|
  Rat   520 ----RETRKNAKIISSRDD------------QGTAKPFTEEDFQEMIKSAQIMESQYGHLFDKII 568

  Fly   605 VNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            :|:|....|.::..|.|::..:..||||:|::
  Rat   569 INDDLTVAFNELKTTFDKLETDAHWVPVSWLH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	13/22 (59%)
		PDZ_signaling	173..250	CDD:238492	30/79 (38%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:279019	67/219 (31%)
		GuKc	418..622	CDD:214504	61/203 (30%)
Mpp7	XP_017456050.1	L27	16..68	CDD:197794	2/2 (100%)
		L27	<88..125	CDD:197794	16/59 (27%)
		PDZ_signaling	137..217	CDD:238492	32/83 (39%)
		SH3_MPP7	232..292	CDD:212966	29/59 (49%)
		GuKc	409..588	CDD:214504	59/198 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740