DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and Guk1

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_006246539.1	Gene:	Guk1 / 303179	RGDID:	1309638	Length:	266	Species:	Rattus norvegicus

Alignment Length:	218	Identity:	67/218 - (30%)
Similarity:	101/218 - (46%)	Gaps:	34/218 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 KTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNE 474
            :.:||.|.||.|:.||..:|.......||..:.||:|..|..||:|..|:|:.||.|:..:...:
  Rat    73 RPVVLSGPSGAGKSTLLKKLFQEHGSVFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGD 137

  Fly   475 FLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTI 539
            |:|:.|.:||||||..::::.|....|:|:||.....::.:..: :|.|..|.|..|.|:.|:.
  Rat   138 FIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQGVRSIKKT-DLHPIYISVQPPSMDVLEQ- 200

  Fly   540 YADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVI 604
                                 |...|...|.||||.     .|.|.  ::.....|....||:||
  Rat   201 ---------------------RLRQRNTETEESLAK-----RLAAA--QADMESSKEPGLFDLVI 237

  Fly   605 VNEDFDETFRQVVETLDQMSHEE 627
            ||::.||.:    .||.|...||
  Rat   238 VNDNLDEAY----VTLKQALSEE 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918
		PDZ_signaling	173..250	CDD:238492
		SH3_MPP	287..347	CDD:212796
		Guanylate_kin	408..622	CDD:279019	64/211 (30%)
		GuKc	418..622	CDD:214504	61/203 (30%)
Guk1	XP_006246539.1	Guanylate_kin	71..256	CDD:279019	65/216 (30%)
Guk1	XP_006246539.1	guanyl_kin	73..255	CDD:213788	65/215 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810