Protein Alignment vari and Lrguk

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_017448017.1
• Gene: Lrguk / 296968
• RGDID: 1308226
• Length: 1271
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 135/677 - (19%)
• Similarity: 243/677 - (35%)
• Gaps: 218/677 - (32%)

  Fly    13 RQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIF--------LKGLLRSNSNTP--HKEL 67
            |..:.|:.....:..||.:.|:.:..:|..|  ::|.:.        |.||..|...|.  ::.|
  Rat    69 RSHEAEVEQEEQQEEGESEESEESEMQNLED--EYDGVLREENVADALDGLGWSGRGTEQVYRNL 131

  Fly    68 MLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPS-RRLESRELAKLLAQPHFRALLRAHDEIGAL 131
            .|:..|...|.: |..:::        ::|.:.| .|:|  :|:.:...|:...|..:.:.:...
  Rat   132 NLSHCELIDVSI-LSGYVH--------LQKLNLSGNRIE--DLSCVSCMPYLLELNASQNRLTTF 185

  Fly   132 YE----QRLKAAGGSTSQLEIASQRQTGGY-LFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVE 191
            :.    |.||.....:|. :|:.......| ..|:.:|:..   |..::.||    .|.:.|| .
  Rat   186 FNFKPPQNLKQKVDFSSN-QISEMYDLSAYHTLTQLILDNN---EIEEITGL----EKCISLT-H 241

  Fly   192 LDEFKQLVVARILAGGVIDKQSMLHVGDV---ILEVNGTPVRTPDELQVEVSRAKENLTLKIGPN 253
            |.          |||..|  .::..:|.:   :|.|:...:.|...|  |..:|.:||.|
  Rat   242 LS----------LAGNRI--TTIKGLGTLPIKVLSVSNNQIETITGL--EELKALQNLDL----- 287

  Fly   254 VDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQ 318
                             ..|.|:||.                            ||  ::.|:|:
  Rat   288 -----------------SHNQISSLH----------------------------GL--ENHDLLE 305

  Fly   319 IINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICG------------- 370
            :||::|             :||     :||.         |.:|:..:.|..
  Rat   306 VINLED-------------NKI-----KELS---------EIEYIENLPILRVLNLLRNPIQTKP 343

  Fly   371 -------------TRISKRKRKTMYRSVANCEFD-KAELLLYEE-----VTRMPPFRR------- 409
                         |.:.::|.|...:..|..::| ..|::..::     |..|...:|
  Rat   344 EYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKYDPPPEVVAAQDHMTHVVNSMSQPQRIFDSTLP 408

  Fly   410 ------KTLVLIGVSGVGRRTLKNRLIN--SDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEM 466
                  ..|:|.|....|:|.|.:||..  |...::||.  ||:||....|.:...|.|:.:|..
  Rat   409 SLDAPYPMLILTGPEACGKRELAHRLCRQFSTYFRYGAC--HTTRPPYFGEGDRVDYHFVSQEVF 471

  Fly   467 EEAVRNNEFL---EYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFV 528
            :|.:...:|:   .||.||   ||.:..:::.:...|   :..|       :|...|
  Rat   472 DEMLSMGKFILTFNYGNHN---YGLNRDTVEGIARDG---LASC-------IHMELE-------- 515

  Fly   529 AAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQ 593
               |:..||..|.:.|..   ..:..|::....:..|:     .|.|..|.:..|:.|:....|.
  Rat   516 ---GIRSLKYSYFEPRYI---LVVPMDKEKYEGYLRRK-----GLFSRAEIEIAVSRVDLYVKVN 569

  Fly   594 RKYEKYFDMVIVNEDFDETFRQVVETL 620
            ||:..|||.||..:|.|..::::.|.:
  Rat   570 RKFPGYFDAVINADDLDIAYQKLSELI 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	4/22 (18%)
		PDZ_signaling	173..250	CDD:238492	20/79 (25%)
		SH3_MPP	287..347	CDD:212796	9/59 (15%)
		Guanylate_kin	408..622	CDD:279019	55/231 (24%)
		GuKc	418..622	CDD:214504	51/208 (25%)
Lrguk	XP_017448017.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810