DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Dlg4

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_062567.1	Gene:	Dlg4 / 29495	RGDID:	68424	Length:	724	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	157/641 - (24%)
Similarity:	272/641 - (42%)	Gaps:	170/641 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NKVNGEDDTSDN--AAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHLN 86
            |.|..||...::  ||.:|:     :|.::||....||:      .:.:...|..:......||:
  Rat   216 NSVGLEDVMHEDAVAALKNT-----YDVVYLKVAKPSNA------YLSDSYAPPDITTSYSQHLD 269

  Fly    87 NKPICDDII-------------RKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKA 138
            |:......:             |::||.                      |.|.:|
  Rat   270 NEISHSSYLGTDYPTAMTPTSPRRYSPV----------------------AKDLLG--------- 303

  Fly   139 AGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLT-VELDEFKQLVVAR 202
                                 .||:     |.|..::| :.|. |..||.. |..::.:.:.::.
  Rat   304 ---------------------EEDI-----PREPRRIV-IHRG-STGLGFNIVGGEDGEGIFISF 340

  Fly   203 ILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSG 267
            |||||..|....|..||.||.|||..:|.....|..::......|:.|......| :..|:....
  Rat   341 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPE-EYSRFEAKI 404

  Fly   268 GQVKQ--------NGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDI--GLPFKSGDILQIINV 322
            ..:::        :|.|||.:..|...|:||||.|:.::|    |..:  .|.|:.||:|.:|:.
  Rat   405 HDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD----CGFLSQALSFRFGDVLHVIDA 465

  Fly   323 KDPNWWQAKNI--TAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSV 385
            .|..||||:.:  .:|:|.||.|||:...|||:                   .|:.|.|. :.|.
  Rat   466 GDEEWWQARRVHSDSETDDIGFIPSKRRVERRE-------------------WSRLKAKD-WGSS 510

  Fly   386 ANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNR----LINSDVDKFGAVIPHTSR 446
            :..:..:..:|.||.||:|.....:.::::|.:       |:|    |::...||||:.:|||:|
  Rat   511 SGSQGREDSVLSYETVTQMEVHYARPIIILGPT-------KDRANDDLLSEFPDKFGSCVPHTTR 568

  Fly   447 PKRALEENGSSYWFM-DREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPN 510
            |||..|.:|..|.|: .||:||:.::.::|:|.|::|.:||||.:||:::|...|:.||||.:.|
  Rat   569 PKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSAN 633

  Fly   511 ALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLAS 575
            |::.| .:..|.|..||:....:|.:..|  ::|.|......:|||.:.:
  Rat   634 AVRRL-QAAHLHPIAIFIRPRSLENVLEI--NKRITEEQARKAFDRATKL--------------- 680

  Fly   576 LYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVP 631
                             ::::.:.|..::..:.|:|.:.:|...::.:|....|||
  Rat   681 -----------------EQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	2/22 (9%)
		PDZ_signaling	173..250	CDD:238492	23/77 (30%)
		SH3_MPP	287..347	CDD:212796	26/63 (41%)
		Guanylate_kin	408..622	CDD:279019	57/218 (26%)
		GuKc	418..622	CDD:214504	56/208 (27%)
Dlg4	NP_062567.1	MAGUK_N_PEST	10..64	CDD:287565
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..35
		PDZ	65..149	CDD:278991
		PDZ	160..244	CDD:278991	10/32 (31%)
		PDZ_assoc	245..312	CDD:287558	16/129 (12%)
		PDZ	310..394	CDD:214570	25/85 (29%)
		SH3_DLG4	430..495	CDD:212963	26/68 (38%)
		Guanylate_kin	533..711	CDD:279019	57/219 (26%)
		GuKc	544..710	CDD:214504	56/200 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810