DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and SPBC1198.05

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_595074.1	Gene:	SPBC1198.05 / 2539674	PomBaseID:	SPBC1198.05	Length:	202	Species:	Schizosaccharomyces pombe

Alignment Length:	218	Identity:	63/218 - (28%)
Similarity:	109/218 - (50%)	Gaps:	36/218 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 TRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEM 466
            :::...:.|.:|:.|.||||:.||..||:....||.|..:.||:|..||.|::|..|.|:.:||.
pombe    11 SKLVTLKLKPVVVFGPSGVGKSTLLKRLLKDHGDKLGFSVSHTTRTPRAGEKDGIDYHFVTKEEF 75

  Fly   467 EEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDC-APNALKILHNSQELMPFVIFVAA 530
            ::.|...:|:|:...:||:|||.:.:|:::....:..|||. ....|::  .:..:....:|:|.
pombe    76 QKLVAEEKFVEWAVFSGNMYGTSIMAIQELEAVNKKAILDIDLQGVLQV--KASPIDAQYVFLAP 138

  Fly   531 PGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRK 595
            |.:|||:.     |..|...    :.:|:|.....|||               |.:|.|
pombe   139 PSIEQLEV-----RLRGRGT----ENESAILQRLERAR---------------AEIEYS------ 173

  Fly   596 YEK--YFDMVIVNEDFDETFRQV 616
             ||  .||.:|||:|.::.::|:
pombe   174 -EKPGNFDALIVNDDVEKAYKQL 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918
		PDZ_signaling	173..250	CDD:238492
		SH3_MPP	287..347	CDD:212796
		Guanylate_kin	408..622	CDD:279019	63/212 (30%)
		GuKc	418..622	CDD:214504	60/202 (30%)
SPBC1198.05	NP_595074.1	Gmk	17..201	CDD:223272	63/212 (30%)
SPBC1198.05	NP_595074.1	guanyl_kin	19..201	CDD:213788	63/210 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810