Protein Alignment vari and pals1a

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_919344.1
• Gene: pals1a / 252845
• ZFINID: ZDB-GENE-020712-1
• Length: 703
• Species: Danio rerio
• Alignment Length: 689
• Identity: 194/689 - (28%)
• Similarity: 324/689 - (47%)
• Gaps: 135/689 - (19%)

  Fly     7 RSRRQ----ARQD-------KVELLARNNKVNGEDDTSDNAAFRN-----------STDLSDHDE 49
            |.||:    :||:       :::.|::|.||.     .||..|..           .:.::....
Zfish    89 RRRREEEGRSRQELDLNSSMRLKKLSQNPKVG-----IDNPTFEQMEGPGGSAGGLQSLIAPPAL 148

  Fly    50 IFLKGLLRSNSNTPHKELMLNPTEPQ-PVPLFLP-----------------AHLNNKP------- 89
            :.|:.||.|.....|.   ||.::.| .|.|.|.                 ||..|:|
Zfish   149 LELEDLLMSLKQVQHS---LNDSQSQEDVELVLQLVQKPDFQKAFSIHNSVAHYMNRPSPPYPLT 210

  Fly    90 -----ICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIA 149
                 :..::......|...|..||:.||:..|.:||:.|||.: |..|.:|:....|.:..|..
Zfish   211 DHAQTLAQEVEVMVQNSSHKEGLELSSLLSTSHMQALMMAHDSV-AEQEMQLEPLVPSVNASETL 274

  Fly   150 SQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSM 214
            :  |.||              ||:|:|.:.:....|||.||. ::...:|::||:.||..::..:
Zfish   275 T--QWGG--------------ETVKIVRIEKAKDIPLGATVR-NDMDSVVISRIVKGGAAERSGL 322

  Fly   215 LHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLE 279
            ||.||.|||:||..:|..|..:|....|..:..|..            ..:...|:|...|
Zfish   323 LHEGDEILEINGVEIRGKDVNEVFDILADMHGVLSF------------VLIPSAQIKSPPI---- 371

  Fly   280 TGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDK--IGL 342
              |:...:::|.|.|:||:|..:|||::||.|:.||||.||:..|||||||.....|.::  .||
Zfish   372 --KETVVHVKAHFDYDPSDDPYVPCRELGLCFQKGDILHIISQDDPNWWQAYRDGDEDNQPLAGL 434

  Fly   343 IPSQELEERRKAF--VAPEADYVHKIG--ICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVT- 402
            :|.:..:::|:|.  ...|.....|.|  .|..:..|:::|..|.:..|.:||..|:|.|||:.
Zfish   435 VPGKSFQQQREAMKQTIEEDKEPEKTGKLWCAKKTKKKRKKMQYNANKNDDFDNEEILTYEEMAL 499

  Fly   403 -RMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEM 466
             ..|..|::.:.|||....|:..|:.||::::.|:|...:|||:|.:|..|.||..|.|:.|:..
Zfish   500 YHQPANRKRPIALIGPPNCGQNELRQRLLSTEPDRFAGPVPHTTRSRRDAEANGRDYHFVSRQAF 564

  Fly   467 EEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAP 531
            |......:|:|.||...|.|||...|::.|||:|::|:|.....:||:|.:| :|.|::||:|.|
Zfish   565 EMDSAAGKFIESGEFEKNFYGTSTDSVRQVINTGKICLLCVHTQSLKVLRSS-DLKPYIIFIAPP 628

  Fly   532 GMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKY 596
            ..|:|:.:.|.     .|:|                         .:.::|...:|::..:::.|
Zfish   629 SQERLRALLAK-----DNKN-------------------------PKPEELRDIIEKAREMEQNY 663

  Fly   597 EKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWI 635
            ...||..|||.|.|:::::::..::::..|.||||.:|:
Zfish   664 GHLFDAAIVNTDLDKSYQELLRLINKLDTEPQWVPSSWL 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	11/22 (50%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	26/77 (34%)
		SH3_MPP	287..347	CDD:212796	29/61 (48%)
		Guanylate_kin	408..622	CDD:395500	62/213 (29%)
pals1a	NP_919344.1	L27_N	150..197	CDD:462666	11/49 (22%)
		PDZ_MPP5-like	283..362	CDD:467259	26/91 (29%)
		SH3_MPP5	377..439	CDD:212969	29/61 (48%)
		GuKc	519..689	CDD:214504	58/200 (29%)