DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Dlg1

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_038943929.1	Gene:	Dlg1 / 25252	RGDID:	2505	Length:	939	Species:	Rattus norvegicus

Alignment Length:	675	Identity:	167/675 - (24%)
Similarity:	291/675 - (43%)	Gaps:	171/675 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ELLARNNKVNGEDDTSDNA--AFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLF 80
            :|||.|: |..|:.|.:.|  |.:|::|.     ::||              :..||.......:
  Rat   370 KLLAVNS-VCLEEVTHEEAVTALKNTSDF-----VYLK--------------VAKPTSMYINDGY 414

  Fly    81 LPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQ 145
            .|..:.|.. ...:....|||..|.....:.....|..:|:| ..|||
  Rat   415 APPDITNSS-SQSVDNHVSPSSYLGQTPASPARYSPISKAVL-GDDEI----------------- 460

  Fly   146 LEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLT-VELDEFKQLVVARILAGGVI 209
                                |:.|    :.|.|.|. |..||.. |..::.:.:.::.|||||..
  Rat   461 --------------------TREP----RKVVLHRG-STGLGFNIVGGEDGEGIFISFILAGGPA 500

  Fly   210 DKQSMLHVGDVILEVNGTPVR--TPDELQVEVSRAKENLTLKIGPNVDE------EIKSGRYTVS 266
            |....|..||.|:.||...:|  :.::....:..|.:.:|:......:|      :|...|..:.
  Rat   501 DLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMM 565

  Fly   267 GGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAK 331
            ...| .:|..||.|.:|.:.|:||||.|:.::||.||.:  ||.||.||||.:||..|..||||:
  Rat   566 NSSV-SSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQAR 627

  Fly   332 NIT--AESDKIGLIPSQELEERRKAFVAPEADYVHKI-GICGTRISKRKRKTM-------YRSVA 386
            .:|  .|||::|:|||:...|:::........:..|. |..|...:.:::|.:       |::..
  Rat   628 QVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRGDKGQSFNDKRKKNLFSRKFPFYKNKD 692

  Fly   387 NCEFDKAE----------------------------------LLLYEEVTRMPPFRRKTLVLIGV 417
            ..|.:.::                                  :|.||.|.:......:.::::|
  Rat   693 QSEQETSDADQHVTSNASDSESSYLILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILG- 756

  Fly   418 SGVGRRTLKNRLINSDV-----DKFGAVIPHTSRPKRALEENGSSYWFM-DREEMEEAVRNNEFL 476
                  .:|:| :|.|:     ||||:.:|||:||||..|.:|..|.|: .||:||:.::.::|:
  Rat   757 ------PMKDR-VNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFI 814

  Fly   477 EYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYA 541
            |.|::|.:||||.:||::.|...|:.||||.:.||:|.|..:| |.|..||:....||.:..:
  Rat   815 EAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQ-LYPISIFIKPKSMENIMEM-- 876

  Fly   542 DRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVN 606
            ::|.|......:|:|  ::|                              :::::.::|..::..
  Rat   877 NKRLTDEQARKTFER--AVR------------------------------LEQEFTEHFTAIVQG 909

  Fly   607 EDFDETFRQVVETLDQMSHEEQWVP 631
            :..::.:.||.:.:::.|....|||
  Rat   910 DTLEDIYNQVKQIIEEQSGPYIWVP 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	4/22 (18%)
		PDZ_signaling	173..250	CDD:238492	22/79 (28%)
		SH3_MPP	287..347	CDD:212796	33/61 (54%)
		Guanylate_kin	408..622	CDD:279019	59/219 (27%)
		GuKc	418..622	CDD:214504	58/209 (28%)
Dlg1	XP_038943929.1	PDZ_signaling	224..308	CDD:238492
		PDZ_signaling	317..403	CDD:238492	13/52 (25%)
		PDZ_assoc	404..465	CDD:402299	16/103 (16%)
		PDZ	463..547	CDD:214570	23/88 (26%)
		SH3_DLG1	582..648	CDD:212964	33/67 (49%)
		Guanylate_kin	748..926	CDD:395500	59/220 (27%)
		L27_1	2..62	CDD:401120
		MAGUK_N_PEST	106..223	CDD:402306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810