DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment vari and Dlg2

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:XP_006507830.1 Gene:Dlg2 / 23859 MGIID:1344351 Length:1027 Species:Mus musculus


Alignment Length:728 Identity:181/728 - (24%)
Similarity:307/728 - (42%) Gaps:185/728 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SRRQARQDKVELLARNNKVNGEDDTSDNAA--FRNSTDLSDHDEIFLK----------------- 53
            :::..|....:.|...|..:.|:.|.:.|.  .:|::|:     ::||                 
Mouse   376 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDV-----VYLKVGKPTTIYMTDPYGPPD 435

  Fly    54 -----------GLLRSNSNTPHKELMLNPTEP---QPVPLFL-----------PAHLNNKPICDD 93
                       .||..|:.|...:..|.|..|   .|:|..:           |.:.....:|| 
Mouse   436 ITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLGEDDYTRPPEPVYSTVNKLCD- 499

  Fly    94 IIRKFSPSRRLESRELAK--LLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGG 156
              :..|| |.....|..|  ||:.|:      .|..:|.|.:          |.:...||..|. 
Mouse   500 --KPASP-RHYSPVECDKSFLLSTPY------PHYHLGLLPD----------SDMTSHSQHSTA- 544

  Fly   157 YLFTEDVLNTKMPVETI-KMVGLRRDPSKPL------GLTVEL---DEFKQLVVARILAGGVIDK 211
                     |:.|..|: :.:.|..:|.|.:      ||...:   ::.:.:.|:.|||||..|.
Mouse   545 ---------TRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADL 600

  Fly   212 QSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQ---- 272
            ...|..||.||.|||..:|.....|...:......|:.|......| ...|:......:::    
Mouse   601 SGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPE-DYARFEAKIHDLREQMMN 664

  Fly   273 ----NGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNI 333
                :|..||.|.:|.:.|:||:|.|:.|:||.||.:  ||.||.||||.:||..|..||||:.:
Mouse   665 HSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRV 727

  Fly   334 T--AESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRIS---KRKRKTMYR---------- 383
            |  .:|:::|:|||:...||::........:..|.|:..::.|   |||:..::.          
Mouse   728 TLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKE 792

  Fly   384 -------------------SVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRL 429
                               |.::|...:..:|.||.|||......:.::::|       .:|:| 
Mouse   793 QSEQETSDPEQHVSSNASDSESSCRGQEDLILSYEPVTRQEINYTRPVIILG-------PMKDR- 849

  Fly   430 INSDV-----DKFGAVIPHTSRPKRALEENGSSYWF-MDREEMEEAVRNNEFLEYGEHNGNLYGT 488
            ||.|:     ||||:.:|||:||||..|.:|..|.| :.||:||:.::.::|:|.|::|.|||||
Mouse   850 INDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGT 914

  Fly   489 HLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLS 553
            .:||::.|...|:.||||.:.||:|.|..:| |.|..||:....:|.|..:  ::|.|......:
Mouse   915 SVQSVRFVAERGKHCILDVSGNAIKRLQVAQ-LYPIAIFIKPKSLEPLMEM--NKRLTEEQAKKT 976

  Fly   554 FDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVE 618
            :||...:                                ::::.:||..::..:..::.:.|...
Mouse   977 YDRAIKL--------------------------------EQEFGEYFTAIVQGDTLEDIYNQCKL 1009

  Fly   619 TLDQMSHEEQWVP 631
            .:::.|....|:|
Mouse  1010 VIEEQSGPFIWIP 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 6/24 (25%)
PDZ_signaling 173..250 CDD:238492 23/86 (27%)
SH3_MPP 287..347 CDD:212796 31/61 (51%)
Guanylate_kin 408..622 CDD:279019 60/219 (27%)
GuKc 418..622 CDD:214504 59/209 (28%)
Dlg2XP_006507830.1 L27_1 4..63 CDD:370268
MAGUK_N_PEST 158..240 CDD:371162
PDZ_signaling 241..325 CDD:238492
PDZ_signaling 334..419 CDD:238492 9/47 (19%)
PDZ_assoc 421..488 CDD:371157 9/66 (14%)
PDZ_signaling 562..640 CDD:238492 22/77 (29%)
SH3_DLG2 677..750 CDD:212965 34/74 (46%)
Guanylate_kin 836..1014 CDD:366206 60/220 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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