DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and PDZD2

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens

Alignment Length:	321	Identity:	59/321 - (18%)
Similarity:	109/321 - (33%)	Gaps:	117/321 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVRWSARSRRQARQDKVELLAR-------------------NNKVNGEDDTSDNAAFRNSTDLSD 46
            ||:....|:..:.:|.:.|.::                   :.:.:||:|...:::.:.:...:|
Human   410 MVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTD 474

  Fly    47 H---------------------DEIFLK-----GLLRSNSNTPHKELMLNPTEPQPVPLFLPAHL 85
            .                     ::|.||     |:.|..|...:.|||:...:|:
Human   475 EPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPR---------- 529

  Fly    86 NNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRL-KAAGGSTSQLEIA 149
                     ||....||......|.:||            |...|..|..: |.:..|.|..::.
Human   530 ---------IRMLEVSRDGRKHSLPQLL------------DSSSASQEYHIVKKSTRSLSTTQVE 573

  Fly   150 SQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTV---------ELDEFKQLVVARILA 205
            |..:    |....|         |.::||.::..|.||.::         ::..|    |..|..
Human   574 SPWR----LIRPSV---------ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIF----VKTIFP 621

  Fly   206 GGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVS 266
            .|...:...|..||.||:|||.|::              .||.:...:..::|:||.:.::
Human   622 NGSAAEDGRLKEGDEILDVNGIPIK--------------GLTFQEAIHTFKQIRSGLFVLT 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	4/22 (18%)
		PDZ_signaling	173..250	CDD:238492	21/85 (25%)
		SH3_MPP	287..347	CDD:212796
		Guanylate_kin	408..622	CDD:279019
		GuKc	418..622	CDD:214504
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492	2/5 (40%)
		PDZ_signaling	589..670	CDD:238492	22/98 (22%)
		PDZ_signaling	726..810	CDD:238492
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900