DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Mpp4

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001158154.1	Gene:	Mpp4 / 227157	MGIID:	2386681	Length:	654	Species:	Mus musculus

Alignment Length:	733	Identity:	187/733 - (25%)
Similarity:	309/733 - (42%)	Gaps:	203/733 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KVELLARNNKVNGEDDTSDNAAFRNSTDLSDHD---------EIFLKGLLRSNSNTPHKELMLNP 71
            |....|.:|...|....||..|     :|::.|         |..|.|:||         |:|
Mouse     6 KAPAAATDNPPAGRMRQSDRGA-----ELTNEDRALPTPPDPENGLSGILR---------LLL-- 54

  Fly    72 TEPQPVPLFLPAHLNNKPICDDII--------------------RKFSP---------------- 100
               |.:.||....:|...:..|::                    :|..|
Mouse    55 ---QELSLFYSRDVNGLCLLYDLLHSPWLQALLKVYDCLQRFKEKKLVPDTTHAQILACEVLELL 116

  Fly   101 ---SRRLESRELAKLLAQPHFRALLRAHDEIGAL-YEQRLKAAGGSTSQLEIASQRQTGGYLFTE 161
               |...|.:||.::|..||.:|||.|||.:... :|..|.....:....|
Mouse   117 PKASGSPEIQELRQVLQAPHCKALLSAHDTVAQKDFEPLLPPLPDNIPDSE-------------- 167

  Fly   162 DVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFK-QLVVARILAGGVIDKQSMLHVGDVILEVN 225
                     |.:::|.|.:: .:|||.|::..|.. .::|||::.||::::..:|:.||.::|||
Mouse   168 ---------EAMRIVCLVKN-QQPLGATIKRHEITGDILVARVIHGGLVERSGLLYAGDKLVEVN 222

  Fly   226 GTPVRTPDELQV--EVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYM 288
            |..|...|..||  .::.:...:..|:.|            ||...|         :.:|:. |:
Mouse   223 GVSVEGLDPEQVIHILAMSCGTIMFKVIP------------VSAPPV---------SSQKMV-YV 265

  Fly   289 RALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERR- 352
            ||:..|.|.||..:||.|.||||..||||||::..|..||||:.|:..:...|||||..|.:|:
Mouse   266 RAMIDYWPQEDPDIPCMDAGLPFLKGDILQIVDQNDALWWQARKISDLTICAGLIPSNHLLKRKQ 330

  Fly   353 ------------------KAFVAPEADYV------------------------------HKIGIC 369
                              :|....|.|.:                              .|..|.
Mouse   331 REFWWSQPYQPHTCLKSTRALSMEEEDSMKIDEKCVEADEETFESEELAEAKDEFVGDGQKFFIA 395

  Fly   370 GTRISKR--KRKTMYRSV-----ANCEFDKAELLLYEEVT---RMPPFRRKTLVLIGVSGVGRRT 424
            |.|.|.|  :||:.:..:     .:|....|....||||.   |.|..:.:.:||:|.||||...
Mouse   396 GFRRSMRLCRRKSHFSQLHASLCCSCSCYSAVGAPYEEVVRYQRQPADKHRLIVLVGPSGVGVNE 460

  Fly   425 LKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTH 489
            |:.:||..:...|.:.:|||:|..::.|.:|..|.::.||..|..:..::.|||||:.|:||||.
Mouse   461 LRRQLIGCNPSCFQSAVPHTTRFPKSYEMDGREYHYVSRETFESLMYGHKMLEYGEYKGHLYGTS 525

  Fly   490 LQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSF 554
            :.::..|::.|::||:|..|..::.. .:::|.|:|||:..|
Mouse   526 VNAVHAVLDEGKICIMDLEPQDIQSA-RTRDLKPYVIFIKPP----------------------- 566

  Fly   555 DRQSSIRFSSRRAR-TLESLASL-YEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVV 617
             ..||:|.|.:.|: |.:....: ::|:||....|.:..::.::.::||.||||::..:...|::
Mouse   567 -NTSSMRHSRKNAKITTDYYVDMKFKDEDLQEMEELAQKMESQFGQFFDHVIVNDNLQDACGQLL 630

  Fly   618 ETLDQMSHEEQWVPVNWI 635
            ..:.:...|.||||..|:
Mouse   631 SAIQKAQEELQWVPEAWV 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	12/22 (55%)
		PDZ_signaling	173..250	CDD:238492	23/79 (29%)
		SH3_MPP	287..347	CDD:212796	31/59 (53%)
		Guanylate_kin	408..622	CDD:279019	60/215 (28%)
		GuKc	418..622	CDD:214504	57/205 (28%)
Mpp4	NP_001158154.1	L27	<66..100	CDD:197794	3/33 (9%)
		L27	108..154	CDD:280918	13/45 (29%)
		PDZ_signaling	171..250	CDD:238492	24/79 (30%)
		SH3_MPP4	264..324	CDD:212967	31/59 (53%)
		Guanylate_kin	446..636	CDD:279019	60/214 (28%)
		GuKc	454..637	CDD:214504	57/207 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740