Protein Alignment vari and magu-1

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_497201.1
• Gene: magu-1 / 190302
• WormBaseID: WBGene00021914
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 559
• Identity: 165/559 - (29%)
• Similarity: 249/559 - (44%)
• Gaps: 109/559 - (19%)

  Fly   107 RELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVE 171
            ::|.:||..|..:.:|.|..||         :||....||              .||     |.|
 Worm    83 QQLVELLNLPRVQGVLWAAQEI---------SAGRFAPQL--------------PDV-----PFE 119

  Fly   172 -------TIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV 229
                   .:|:|.:.| ..:|||.|::.:..| :.||||:|.||.|:...:..||.:|||||..|
 Worm   120 VDEDDGVAVKIVRIVR-RGEPLGATIKCERGK-VYVARIMANGVADRSGCIQEGDRVLEVNGITV 182

  Fly   230 --RTPDELQVEVSRAKEN--LTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRA 290
              :.|.|: |::....:|  :|.|:.|               .::.|    .|:..|....|.||
 Worm   183 ADKEPREI-VKLLDKCDNGIITFKLIP---------------AEINQ----KLKQKKSSHRYARA 227

  Fly   291 LFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNI----------------TAESDK 339
            ||.|:|.:|...||.:..:.|:.||||:|::.||..|||.:.|                ..:|.|
 Worm   228 LFDYDPWQDKRHPCPEAAISFRGGDILEILDEKDQYWWQTRKIGFGALARRKESHDDENRDDSKK 292

  Fly   340 IGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRM 404
            :||:||:.|:                   |.:.|.:....|.....:..|..|..  .||.|.|.
 Worm   293 VGLVPSEWLQ-------------------CQSEIPENGIDTSDDFQSFLENHKGR--FYESVFRW 336

  Fly   405 --PPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEME 467
              ...||:.:||:|..||||..::.:......|:|...|||||||:|..|.:|.:|:|..|.|||
 Worm   337 RNKKKRRRVVVLLGAPGVGRNEIRRQFFKVFADRFTNAIPHTSRPQRPNESDGVNYYFTSRSEME 401

  Fly   468 EAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILH-NSQELMPFVIFVAAP 531
            ..:...|.|||||...|||||.|:|::.....|.:.:   .|:.|.|.: .:.|..|.||||..|
 Worm   402 RMIERKEMLEYGEFRDNLYGTALKSVRKASEKGTVLL---TPHPLAIENIRTWEFAPIVIFVQPP 463

  Fly   532 GMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKY 596
            ...:.|   ..|....|....|....||...|...|.|  |.|..:.|.::...::.|:.:::||
 Worm   464 EFGEFK---HTREVYRSQTTRSHSAASSSNISQNTAAT--SAARAFSDVEIRQIIDNSAQMEQKY 523

  Fly   597 EKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWI 635
            ..|.|.:|.|.|.|.|..::...:.|:..:..|:|:.|:
 Worm   524 RGYCDAIIRNVDLDTTMNELTGLIYQLESKATWMPMKWL 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	6/20 (30%)
		PDZ_signaling	173..250	CDD:238492	29/80 (36%)
		SH3_MPP	287..347	CDD:212796	28/75 (37%)
		Guanylate_kin	408..622	CDD:279019	73/214 (34%)
		GuKc	418..622	CDD:214504	68/204 (33%)
magu-1	NP_497201.1	PDZ_signaling	128..201	CDD:238492	28/75 (37%)
		SH3_MPP	224..300	CDD:212796	28/75 (37%)
		Guanylate_kin	348..550	CDD:279019	70/209 (33%)
		NK	353..543	CDD:302627	68/197 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I8355
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810