Protein Alignment vari and magu-3

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_491260.2
• Gene: magu-3 / 183676
• WormBaseID: WBGene00016841
• Length: 479
• Species: Caenorhabditis elegans
• Alignment Length: 624
• Identity: 147/624 - (23%)
• Similarity: 250/624 - (40%)
• Gaps: 174/624 - (27%)

  Fly    15 DKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPL 79
            :|:|.:   .|.||::..:|:.. .|.|               |:||...||            .
 Worm    26 EKIENI---EKKNGKEQDADSTK-SNGT---------------SSSNKDGKE------------K 59

  Fly    80 FLPAHLNNKPICDDIIRKFSPSRRLESRELA--KLLAQPHFRALLRAHDEIGALYEQRLKAAGGS 142
            |....:..|...|       |...|:.|.:.  ::|....|.||  |.|.........|:::|
 Worm    60 FEQVEIEEKTEID-------PKTGLKKRTIVTERVLTTKTFHAL--ALDGPSPTMTPILRSSG-- 113

  Fly   143 TSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEF-KQLVVARILAG 206
            |.....|...|:.  :......:.|..|:..::.            .||:::. .||||.:|...
 Worm   114 TKNHNYAPIHQSA--ILLPQYQSRKTTVDAGQLT------------QVEVEKHGGQLVVTKINEK 164

  Fly   207 GVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVK 271
            ...|    |..||||.:|:|..|    ..:.::...|..:.|.:.|       :|.:.....
 Worm   165 SNYD----LKPGDVITQVDGKDV----YFRADIENLKGKVELTVEP-------AGIHCAPAN--- 211

  Fly   272 QNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAE 336
                           :.|...||:...|...||..:.|....||::||:: ||..|.|.:.: .:
 Worm   212 ---------------FHRVQDTYSSHIDVDRPCLWLDLEVNPGDVIQILS-KDEKWMQVRKL-GD 259

  Fly   337 SDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEV 401
            ..::|.:|:.                                                 |..|:|
 Worm   260 LTQVGYLPTS-------------------------------------------------LTMEKV 275

  Fly   402 TRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEM 466
            :.:.||.|:||||:|..|.|||.:|:.|:......|..::|.|||.:|..|..|..|.|:.:||:
 Worm   276 SMLCPFGRRTLVLLGAVGTGRRDIKSMLLRLAPHYFSTIVPLTSRAQRPGEVEGREYQFVRKEEI 340

  Fly   467 EEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAP 531
            .:.:|....:|:||.:..||||...|:::.|.|||||:||.||.::..|:|: |.||||:.|..|
 Worm   341 YQKIREGGMVEWGELDSQLYGTSADSVRNEIRSGRMCVLDAAPQSVNYLYNA-EFMPFVVHVVPP 404

  Fly   532 GMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKY 596
            .:|:                  |.:..::|.:.|....|:|:.            :||:.:..:.
 Worm   405 PIEE------------------FTQLEAVRRTHRTQGQLQSIC------------DESAKIGLEC 439

  Fly   597 EKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWI 635
            :....:.:||.:.|.||:::|::|:.:.:|.||||.:|:
 Worm   440 KSKIHLTLVNRNIDVTFKRLVDSLETLRYETQWVPHSWM 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	7/24 (29%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	18/78 (23%)
		SH3_MPP	287..347	CDD:212796	17/59 (29%)
		Guanylate_kin	408..622	CDD:395500	67/213 (31%)
magu-3	NP_491260.2	CtpA	147..>204	CDD:440556	19/71 (27%)
		SH3	218..268	CDD:473055	15/51 (29%)
		Guanylate_kin	282..464	CDD:395500	66/212 (31%)