DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and lin-2

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001024587.1	Gene:	lin-2 / 181400	WormBaseID:	WBGene00002991	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	667	Identity:	203/667 - (30%)
Similarity:	321/667 - (48%)	Gaps:	131/667 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KVNGEDDTSDNAAFRNS------TDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPA 83
            ||.|..|..::....||      |....||:..::.|||.     :.::...|.|  ||...:..
Worm   371 KVLGSLDAINSLLDPNSYKPGSTTFQKIHDDGSVRNLLRL-----YDKIKALPCE--PVVTEVDT 428

  Fly    84 HLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGA-LYEQRLKAAGGSTSQLE 147
            ....|...:.|.....||.  |:.||.:||..||..:.::|.|.:.. :.:.:.:|:|....:..
Worm   429 STLRKETLNQIDGLLGPSP--EALELRQLLNSPHLASCVQALDVVVCEIRDPKNEASGSGDKEGN 491

  Fly   148 IASQRQTGGYL------------------FTEDVLNTKMPVE---------TIKMVGLRRDPSKP 185
            ..|......||                  |.:..::|....|         .:::|..::|..:|
Worm   492 CVSSDPAPAYLNGGVLPLGAQRAGTSFEHFNQSAVHTSYDEEEEELYDCMSRLRLVQFQKDTQEP 556

  Fly   186 LGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTL 248
            :|:|::::|..:..||||:.||:|.:|:.|||||.|.|:||..|  |:.:.||..:..|:..:|.
Worm   557 MGITLKVNEDGRCFVARIMHGGMIHRQATLHVGDEIREINGMSVANRSVESLQEMLRDARGQVTF 621

  Fly   249 KIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKS 313
            ||       |.|.|......::                ::||.|.|.||:|.|:||...|:|||:
Worm   622 KI-------IPSYRSAPPACEI----------------FVRAQFDYEPSQDDLIPCPQAGIPFKT 663

  Fly   314 GDILQIINVKDPNWWQAKNITA--------------ESDKIGLIPSQELEERRKAFVAPEADYVH 364
            |||||:|:..|.|||||:.:::              :....|||||.||:|.|.|.:|.|    .
Worm   664 GDILQVISKDDHNWWQARFVSSFPSIGNSSNAQRSNQQQVAGLIPSPELQEWRTACLAME----R 724

  Fly   365 KIGICGTR---ISKRKR--KTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRT 424
            ....|.|.   .:|:|:  .|.|....:..||:.:|:.||||.|:..:|||||||:|..|||||.
Worm   725 SKNTCNTHCMWFNKKKKYYTTKYLQKHSALFDQLDLVTYEEVMRLSQYRRKTLVLLGAHGVGRRH 789

  Fly   425 LKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTH 489
            :||.||:...::|...||||:||.|..|.:|..|:|:..|:|...::|||:||||.|..::|||.
Worm   790 IKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKHYYFVTNEQMMADIQNNEYLEYGTHEESMYGTK 854

  Fly   490 LQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSF 554
            |::|:::..||::.|||..|.|||:|..: |..|||:|:|||.::.::.
Worm   855 LETIRNIHKSGKIAILDVEPQALKVLRTA-EYSPFVVFIAAPNLQGMQD---------------- 902

  Fly   555 DRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVET 619
                                   .|..|...:.||..:::.:...||.:|.|.|.|:|..|:...
Worm   903 -----------------------PDGSLEKLLNESDVLRQAFGHLFDFIITNSDIDDTIAQLERL 944

  Fly   620 LDQMSHEEQWVPVNWIY 636
            ::::....||:||.|:|
Worm   945 VEKLPAYPQWLPVTWVY 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	9/22 (41%)
		PDZ_signaling	173..250	CDD:238492	29/78 (37%)
		SH3_MPP	287..347	CDD:212796	31/73 (42%)
		Guanylate_kin	408..622	CDD:279019	74/213 (35%)
		GuKc	418..622	CDD:214504	66/203 (33%)
lin-2	NP_001024587.1	PKc_like	13..312	CDD:304357
		S_TKc	19..281	CDD:214567
		L27	372..422	CDD:280918	13/56 (23%)
		L27	431..478	CDD:280918	13/48 (27%)
		PDZ	546..624	CDD:278991	31/84 (37%)
		SH3_MPP1-like	637..712	CDD:212968	31/74 (42%)
		Guanylate_kin	773..948	CDD:279019	74/214 (35%)
		GuKc	783..947	CDD:214504	66/203 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920