DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Mpp1

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_032647.1	Gene:	Mpp1 / 17524	MGIID:	105941	Length:	466	Species:	Mus musculus

Alignment Length:	491	Identity:	169/491 - (34%)
Similarity:	260/491 - (52%)	Gaps:	82/491 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 TEDVLNTKMP------------VETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQ 212
            |||:.....|            ...::::...:...:|:|:|::|:|.:...|||||.||:|.:|
Mouse    44 TEDMYTNGSPAPGSPAHAKGQEARRVRLIQFEKITEEPMGITLKLNEKQSCTVARILHGGMIHRQ 108

  Fly   213 SMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGI 275
            ..|||||.|||:|||.|  .:.|:||..:...|..::||:..|                 :|:.:
Mouse   109 GSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIAN-----------------QQSRL 156

  Fly   276 ASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKI 340
            .:|:      .:|||.|.|:|.:|:|:||::.||.|.:|||:||||..|.||||.:...:..:..
Mouse   157 PALQ------MFMRAQFDYDPQKDNLIPCKEAGLKFVTGDIIQIINKDDSNWWQGRVEGSSKESA 215

  Fly   341 GLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMP 405
            |||||.||:|.|.|.||..|.  .:...|.....|:|.|..|.:..:..||:.:::.||||.|:|
Mouse   216 GLIPSPELQEWRVASVAHSAP--SEAPSCSPFGKKKKCKDKYLAKHSSIFDQLDVVSYEEVVRLP 278

  Fly   406 PFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAV 470
            .|:||||||||.|||||..:||.|::.:.:||....|:|:||.:..||:|..|.|:..|||.:.:
Mouse   279 AFKRKTLVLIGASGVGRSHIKNGLLSHNPEKFAYPAPYTTRPPKKSEEDGKEYHFISTEEMTKNI 343

  Fly   471 RNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQ 535
            ..|||||:|.:.||::||..:::..:....::.|||..|..||.:..: ||.||::|: ||..:.
Mouse   344 SANEFLEFGSYQGNMFGTKFETVHQIHKQDKIAILDIEPQTLKTVRTA-ELSPFIVFI-APTDQG 406

  Fly   536 LKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYF 600
            .:|                                |:|..|.:|         |..::.:|..||
Mouse   407 TQT--------------------------------EALQQLQKD---------SEAIRSQYAHYF 430

  Fly   601 DMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            |:.:||...|||.:::.|..||.....|||||:|:|
Mouse   431 DLSLVNNSVDETLKKLQEAFDQACSSPQWVPVSWVY 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918
		PDZ_signaling	173..250	CDD:238492	31/78 (40%)
		SH3_MPP	287..347	CDD:212796	30/59 (51%)
		Guanylate_kin	408..622	CDD:279019	69/213 (32%)
		GuKc	418..622	CDD:214504	61/203 (30%)
Mpp1	NP_032647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..65		4/20 (20%)
		PDZ	71..149	CDD:278991	32/77 (42%)
		SH3_MPP1	162..223	CDD:213013	30/60 (50%)
		Interaction with PALS1. /evidence=ECO:0000250	268..466		84/240 (35%)
		Guanylate_kin	281..453	CDD:279019	70/214 (33%)
		GuKc	291..454	CDD:214504	63/205 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750