DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and DLG4

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_011522001.1	Gene:	DLG4 / 1742	HGNCID:	2903	Length:	797	Species:	Homo sapiens

Alignment Length:	641	Identity:	157/641 - (24%)
Similarity:	272/641 - (42%)	Gaps:	170/641 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NKVNGEDDTSDN--AAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHLN 86
            |.|..||...::  ||.:|:     :|.::||....||:      .:.:...|..:......||:
Human   289 NSVGLEDVMHEDAVAALKNT-----YDVVYLKVAKPSNA------YLSDSYAPPDITTSYSQHLD 342

  Fly    87 NKPICDDII-------------RKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKA 138
            |:......:             |::||.                      |.|.:|
Human   343 NEISHSSYLGTDYPTAMTPTSPRRYSPV----------------------AKDLLG--------- 376

  Fly   139 AGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLT-VELDEFKQLVVAR 202
                                 .||:     |.|..::| :.|. |..||.. |..::.:.:.::.
Human   377 ---------------------EEDI-----PREPRRIV-IHRG-STGLGFNIVGGEDGEGIFISF 413

  Fly   203 ILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSG 267
            |||||..|....|..||.||.|||..:|.....|..::......|:.|......| :..|:....
Human   414 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPE-EYSRFEAKI 477

  Fly   268 GQVKQ--------NGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDI--GLPFKSGDILQIINV 322
            ..:::        :|.|||.:..|...|:||||.|:.::|    |..:  .|.|:.||:|.:|:.
Human   478 HDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD----CGFLSQALSFRFGDVLHVIDA 538

  Fly   323 KDPNWWQAKNI--TAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSV 385
            .|..||||:.:  .:|:|.||.|||:...|||:                   .|:.|.|. :.|.
Human   539 SDEEWWQARRVHSDSETDDIGFIPSKRRVERRE-------------------WSRLKAKD-WGSS 583

  Fly   386 ANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNR----LINSDVDKFGAVIPHTSR 446
            :..:..:..:|.||.||:|.....:.::::|.:       |:|    |::...||||:.:|||:|
Human   584 SGSQGREDSVLSYETVTQMEVHYARPIIILGPT-------KDRANDDLLSEFPDKFGSCVPHTTR 641

  Fly   447 PKRALEENGSSYWFM-DREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPN 510
            |||..|.:|..|.|: .||:||:.::.::|:|.|::|.:||||.:||:::|...|:.||||.:.|
Human   642 PKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSAN 706

  Fly   511 ALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLAS 575
            |::.| .:..|.|..||:....:|.:..|  ::|.|......:|||.:.:
Human   707 AVRRL-QAAHLHPIAIFIRPRSLENVLEI--NKRITEEQARKAFDRATKL--------------- 753

  Fly   576 LYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVP 631
                             ::::.:.|..::..:.|:|.:.:|...::.:|....|||
Human   754 -----------------EQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	2/22 (9%)
		PDZ_signaling	173..250	CDD:238492	23/77 (30%)
		SH3_MPP	287..347	CDD:212796	26/63 (41%)
		Guanylate_kin	408..622	CDD:279019	57/218 (26%)
		GuKc	418..622	CDD:214504	56/208 (27%)
DLG4	XP_011522001.1	L27	<26..49	CDD:413432
		MAGUK_N_PEST	54..137	CDD:402306
		PDZ	138..222	CDD:395476
		PDZ	233..317	CDD:395476	10/32 (31%)
		PDZ_assoc	318..385	CDD:402299	16/129 (12%)
		PDZ	383..467	CDD:214570	25/85 (29%)
		SH3_DLG4	503..568	CDD:212963	26/68 (38%)
		Guanylate_kin	606..784	CDD:395500	57/219 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810