DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and DLG3

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_006724688.1	Gene:	DLG3 / 1741	HGNCID:	2902	Length:	849	Species:	Homo sapiens

Alignment Length:	656	Identity:	174/656 - (26%)
Similarity:	288/656 - (43%)	Gaps:	131/656 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NGEDDTSDNAAFRNSTDLSD--HDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHLNNKP 89
            :|.....|.....|:|:|.|  |:|     .:.|..||... :.|...:|..:      |||:..
Human   269 DGRLQIGDRLLAVNNTNLQDVRHEE-----AVASLKNTSDM-VYLKVAKPGSL------HLNDMY 321

  Fly    90 ICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQT 154
            ...|....|:            .||..|    :..:..:|.|.....|.:..:..|:........
Human   322 APPDYASTFT------------ALADNH----ISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPI 370

  Fly   155 GGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLT-VELDEFKQLVVARILAGGVIDKQSMLHVG 218
            ..::..|:.. |:.|.:.|...|     |..||.. |..::.:.:.|:.|||||..|....|..|
Human   371 PRHMLAEEDF-TREPRKIILHKG-----STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRG 429

  Fly   219 DVILEVNGTPVR--TPDELQVEVSRAKENLTLKIGPNVDE------EIKSGRYTVSGGQVKQNGI 275
            |.||.|||..:|  |.::....:.||.:::|:......:|      :|...|..:....: .:|.
Human   430 DRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSM-SSGS 493

  Fly   276 ASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNIT--AESD 338
            .||.|.:|.:.|:||||.|:.:.||.||.:  ||.|..||||.:||..|..||||:.:|  .||:
Human   494 GSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESE 556

  Fly   339 KIGLIPSQELEERRKAFVAPEADYVHKIG-ICGTRISKRKRKTMYRSVANCEFDKAE-------- 394
            :||:|||::..|:::........:..:.| |...|..|.|||..:|......|.|::
Human   557 QIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESS 621

  Fly   395 -----------------------LLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDV-- 434
                                   :|.||.|||......:.::::|       .:|:| :|.|:
Human   622 IQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILG-------PMKDR-VNDDLIS 678

  Fly   435 ---DKFGAVIPHTSRPKRALEENGSSYWF-MDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKD 495
               .|||:.:|||:||:|..|.:|..|.| :.||:||:.:::|:|:|.|:.|.|||||.:||::.
Human   679 EFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRA 743

  Fly   496 VINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSI 560
            |...|:.||||.:.||:|.|..:| |.|..||:....:|.|..:  :||.|....|..:|:...:
Human   744 VAERGKHCILDVSGNAIKRLQQAQ-LYPIAIFIKPKSIEALMEM--NRRQTYEQANKIYDKAMKL 805

  Fly   561 RFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSH 625
                                            ::::.:||..::..:..:|.:.::.:.::..|.
Human   806 --------------------------------EQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSG 838

  Fly   626 EEQWVP 631
            ...|||
Human   839 HYIWVP 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	3/22 (14%)
		PDZ_signaling	173..250	CDD:238492	26/79 (33%)
		SH3_MPP	287..347	CDD:212796	32/61 (52%)
		Guanylate_kin	408..622	CDD:279019	59/219 (27%)
		GuKc	418..622	CDD:214504	58/209 (28%)
DLG3	XP_006724688.1	MAGUK_N_PEST	52..130	CDD:402306
		PDZ_signaling	131..208	CDD:238492
		PDZ_signaling	224..310	CDD:238492	12/46 (26%)
		PDZ_assoc	311..385	CDD:402299	15/96 (16%)
		PDZ_signaling	384..462	CDD:238492	27/82 (33%)
		SH3_DLG3	502..568	CDD:212962	32/67 (48%)
		Guanylate_kin	658..836	CDD:395500	59/220 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810