DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and Card14

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_006532429.1	Gene:	Card14 / 170720	MGIID:	2386258	Length:	1029	Species:	Mus musculus

Alignment Length:	639	Identity:	127/639 - (19%)
Similarity:	220/639 - (34%)	Gaps:	224/639 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DDTSDNAAFR--NSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICD 92
            |||..:..|.  :..|||..:: .|:|..||          ||.:|    .|.||||.:
Mouse   515 DDTDTDLEFEMIDGADLSQTED-SLQGSSRS----------LNVSE----RLCLPAHSS------ 558

  Fly    93 DIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGY 157
                  .|.||..:|   |:|:|....|.     :..||.|| :...||:.:.:.|  .|.|.|.
Mouse   559 ------VPVRRRPAR---KILSQVTVLAF-----QGDALLEQ-IGVIGGNLTGIFI--HRVTPGS 606

  Fly   158 LFTEDVLNTKMPVETIKMVGLRRDPSKP-LGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVI 221
            ...|..|.   |...|.||..:  |:|| |..|:|....:|.|                   .::
Mouse   607 AADEMALR---PGTQIMMVDYK--PTKPSLRATLENTTLEQAV-------------------GLL 647

  Fly   222 LEVNGTPVRTPDELQVEV-SRAKENLTLKIGPNVDEEIKSGR--YTVSGGQVKQNGIASLETGKK 283
            ..|||:..     |.|:: :...:||...:...|   :.||.  |......:::.|...|:|
Mouse   648 RRVNGSCY-----LSVKINTEGYKNLIQDLDAKV---VTSGDSFYIRVNLAMQRGGDGELQT--- 701

  Fly   284 LTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDP-----NWWQAKNI---TAESDKI 340
                               .|.|            |::|.|.     :.|.|.::   |.:..:.
Mouse   702 -------------------HCND------------ILHVTDTMFQGRSCWHAHHVNPYTMKDMEP 735

  Fly   341 GLIPS-QELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRM 404
            |.||: .:.:::..|.:.                ...:|.|:.|.|.:       |:|   :...
Mouse   736 GTIPNYSQAQQQLLALIQ----------------DMTQRCTVPRKVGH-------LVL---LGHR 774

  Fly   405 PPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRA-----LEENGSS--YW--- 459
            .||...|.:.:.....|.:.|. |:::  ||| .||.|.||...::     .||.|.|  :|
Mouse   775 APFTLSTHLSLSKPPGGPQKLV-RIVS--VDK-AAVSPLTSSFDQSQWDSGKEEGGPSVCFWSES 835

  Fly   460 ------------------------------------------------FMDREEMEEAVRNNEFL 476
                                                            ::.:||.....:..:.:
Mouse   836 CFTLAPYTLVHPHRPARPRPVLFVPRLVGRILGKKLCLLQGFKQCSAEYLSQEEYATWSQRGDII 900

  Fly   477 EYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYA 541
            :.||..|:.:.....:::.::|.....:||...:::::||. .::.|.:|.|:.    ..||  |
Mouse   901 QEGESIGDHHWITRHAVESLMNMSTHALLDVRLDSVRVLHR-MDMFPIIIHVSV----NEKT--A 958

  Fly   542 DRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYED---------DDLVATV 586
            .:...|.:| |....:..:..:.:....|:.:..||..         |.|::.|
Mouse   959 KKLRKGLHR-LGSSEEQFLEVARQEEGELDRVPCLYSSLAPDSWSDLDSLLSCV 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	5/22 (23%)
		PDZ_signaling	173..250	CDD:238492	18/78 (23%)
		SH3_MPP	287..347	CDD:212796	11/68 (16%)
		Guanylate_kin	408..622	CDD:279019	42/246 (17%)
		GuKc	418..622	CDD:214504	41/236 (17%)
Card14	XP_006532429.1	DD	19..104	CDD:387368
		Smc	<132..410	CDD:224117
		PDZ_signaling	587..659	CDD:238492	24/102 (24%)
		SH3	684..745	CDD:388381	15/94 (16%)
		NK	<884..1008	CDD:388413	23/131 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900