DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Patj

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_038965114.1	Gene:	Patj / 140581	RGDID:	1565362	Length:	1858	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	113/629 - (17%)
Similarity:	205/629 - (32%)	Gaps:	208/629 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAH---LNNK 88
            ||:...:|.....:..::.......:..:||:.....|..|:...|.....|...|:.   :...
  Rat   409 NGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLVRRKTSLSASPFEQPSSREAVAEP 473

  Fly    89 PICDDIIRKFSP--SRRLESRELAKLLAQ----------------------PHFRALLRAHDEIG 129
            |...::.....|  :.|:|:.|:.:.|..                      |......|..:.:|
  Rat   474 PEVPELTGSLKPETNSRMEAEEIGERLDNLRKDTVQALEKPDVYPEDIPGCPENELKSRWENLLG 538

  Fly   130 ALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDE 194
            ..||..:     :|...:||...:...|       :..:|:.|::             |.:|:|.
  Rat   539 PDYEVMV-----ATLDTQIADDEELQKY-------SKLLPIHTLR-------------LGMEVDS 578

  Fly   195 FK-QLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEI 258
            |. ...::.|..||.:|..::|...|.:|||||..:..
  Rat   579 FDGHHYISSIAPGGPVDTLNLLQPEDELLEVNGVQLYG--------------------------- 616

  Fly   259 KSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVK 323
            ||.|..||                    :::.:    |...:|:.||.:   |...     .:|.
  Rat   617 KSRREAVS--------------------FLKEV----PPPFTLVCCRRL---FDDE-----ASVD 649

  Fly   324 DPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANC 388
            :|...:...:.||.|: .:..|.|.::...|..:||.                  ||: ..|.:|
  Rat   650 EPRTVEPSLLEAEVDR-SVDVSTEDDDGELALWSPEV------------------KTV-ELVKDC 694

  Fly   389 EFDKAELLLYEEVTRMPPFRR----KTLVLIGVS-------------GVGRRTLKNRLINSDVDK 436
            :.....:|.|::  .:.|.|.    ::||..||:             .|...:|.|..:...|:.
  Rat   695 KGLGFSILDYQD--PLDPMRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEV 757

  Fly   437 FGAVIP---HTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVIN 498
            ..||.|   |....|..:||        ::||.||     .|:.:..:||:             |
  Rat   758 LKAVPPGVVHLGICKPLVEE--------EKEEKEE-----HFIFHSNNNGD-------------N 796

  Fly   499 SGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFS 563
            |.       :|..:..:|:|..|.....|...|.:|:|    .|.......::|.|.:
  Rat   797 SE-------SPETVHEIHSSLILEAPQGFRDEPYLEEL----VDEPFLDLGKSLQFQQ------- 843

  Fly   564 SRRARTLESLASLYEDDDLVAT------VEESSFVQRKYEKYFD 601
                :.::|.:..:|..:.::.      .|....|..:||.|.|
  Rat   844 ----KDMDSSSEAWEMHEFLSPRLERRGEEREMLVDEEYEIYQD 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	5/44 (11%)
		PDZ_signaling	173..250	CDD:238492	15/77 (19%)
		SH3_MPP	287..347	CDD:212796	11/59 (19%)
		Guanylate_kin	408..622	CDD:279019	44/220 (20%)
		GuKc	418..622	CDD:214504	39/206 (19%)
Patj	XP_038965114.1	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492
		PDZ_signaling	366..450	CDD:238492	6/40 (15%)
		CtpA	<391..>511	CDD:223864	16/101 (16%)
		PDZ_signaling	572..636	CDD:238492	21/114 (18%)
		PDZ	684..773	CDD:214570	21/109 (19%)
		PDZ_signaling	1074..1165	CDD:238492
		PDZ	1244..1329	CDD:214570
		PDZ	1471..1578	CDD:214570
		PDZ_signaling	1590..1670	CDD:238492
		PDZ_signaling	1731..1816	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810