DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Mpp3

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_031889.2	Gene:	Mpp3 / 13384	MGIID:	1328354	Length:	585	Species:	Mus musculus

Alignment Length:	662	Identity:	189/662 - (28%)
Similarity:	302/662 - (45%)	Gaps:	149/662 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 STDLSDHDEI-FLKGLLRSNSNTPHKELM---------------------LNPTEPQ-PVPLFLP 82
            |.|...|:.: .|...||.:||  |:|.|                     |...|.| |.|:...
Mouse     5 SEDSGLHETLALLTSQLRPDSN--HREEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHS 67

  Fly    83 AHLNNKPICDDIIRKF-SPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQL 146
            |    ..:.:|::.:. :.|...:.|||.:||:.||.||:|..||.:
Mouse    68 A----MALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTV------------------ 110

  Fly   147 EIASQRQTGGYL-FTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFK-QLVVARILAGGVI 209
               :|:.....| ...|.::.....|::|:|.|.:: .:|||.|:..||.. .:|||||:.||..
Mouse   111 ---AQKNFDPVLPPLPDNIDEDFEEESVKIVRLVKN-KEPLGATIRRDEHSGAVVVARIMRGGAA 171

  Fly   210 DKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQ 272
            |:..::||||.:.||||..|  :.|||:...:::::.::||||.|...||
Mouse   172 DRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEE--------------- 221

  Fly   273 NGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAES 337
                  :..|....:|||||.|:|.||..:||::.||||:...:|::::..||.|||||.:...:
Mouse   222 ------DRFKDSKVFMRALFHYDPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTN 280

  Fly   338 DKIGLIPSQELEERR-------------KAFVAPEAD-----------------YV------HKI 366
            .:.|||||::.:|||             :.|..|..|                 ||      .::
Mouse   281 LRAGLIPSKQFQERRLSYRRTTGTLPSPQNFKKPPYDQPCDKETCDCDGYFKGHYVAGLRRSFRL 345

  Fly   367 GICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTR---MPPFRRKTLVLIGVSGVGRRTLKNR 428
            | |..|:...:...:....     :...||.||||.|   .|..|.:.:||||..|.....||.|
Mouse   346 G-CRERLGGSQEAKVPTGA-----ESQVLLTYEEVARYQHQPGERPRLVVLIGSLGAHLHELKQR 404

  Fly   429 LINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSI 493
            ::..|..:|...:|||:||:::.|.:|..|.|:.::..|..|.:|:|||:||:..|||||.|::|
Mouse   405 VVAEDPQQFAVAVPHTTRPRKSHERDGVEYHFVSKQAFEADVHHNKFLEHGEYKENLYGTSLEAI 469

  Fly   494 KDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQS 558
            :.|:...::|::|..|.||:.| .:.|..|:||||        |....:||.|......|.|..|
Mouse   470 QAVMAKNKVCLVDVEPEALRHL-RTPEFKPYVIFV--------KPAIQERRKTPPVSPDSEDIAS 525

  Fly   559 SIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQM 623
            |:                  |:........::|:.:.|....|.|:|.:|..|...|:...::.:
Mouse   526 SL------------------DEQQQEMAASAAFIDQHYGHLIDTVLVRQDLQEACSQLRAVIETL 572

  Fly   624 SHEEQWVPVNWI 635
            |.:..|||::|:
Mouse   573 SKDTSWVPISWV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	12/22 (55%)
		PDZ_signaling	173..250	CDD:238492	31/79 (39%)
		SH3_MPP	287..347	CDD:212796	28/59 (47%)
		Guanylate_kin	408..622	CDD:279019	65/213 (31%)
		GuKc	418..622	CDD:214504	60/203 (30%)
Mpp3	NP_031889.2	L27	12..64	CDD:197794	12/53 (23%)
		L27	71..121	CDD:197794	16/70 (23%)
		PDZ_signaling	135..215	CDD:238492	32/80 (40%)
		SH3_MPP3	230..291	CDD:212972	28/60 (47%)
		GuKc	395..570	CDD:214504	60/201 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740