Protein Alignment vari and vari

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_061511964.1
• Gene: vari / 1277662
• VectorBaseID: AGAMI1_013877
• Length: 774
• Species: Anopheles gambiae
• Alignment Length: 645
• Identity: 405/645 - (62%)
• Similarity: 499/645 - (77%)
• Gaps: 42/645 - (6%)

  Fly    19 LLARNNKV----NGEDDTSDNAAFR----NSTDLSDHDE------IFLKGLLRSNSNTPHKELML 69
            ||..:.|:    ||      :|||:    |.|||:...|      :||:|:|.:.:.|...::.
Mosquito   145 LLRSSEKIVEFANG------HAAFQHVRENLTDLNGRSEANETDLVFLQGILANPAVTQLIKIQ- 202

  Fly    70 NPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQ 134
            :..|..|.||. |..::|.|:..::|.:.|.||...:||||::...|||||||.||||||....:
Mosquito   203 DKLEEAPAPLH-PVRVDNAPLLKEVIDRCSLSRNPHARELARIFRYPHFRALLEAHDEIGETQLE 266

  Fly   135 RLK-------AAGGSTSQLEIASQRQ-----TGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLG 187
            :||       ::.|..||...||...     :|..|.|   :| .||.|||||||:||:|.:|||
Mosquito   267 KLKHPPTSATSSPGGNSQYHQASPSSETVDGSGVELLT---IN-DMPGETIKMVGIRRNPDEPLG 327

  Fly   188 LTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGP 252
            ||||:||..|||||||:|||:||:|.:||.|||||||||.||.||:|||.|:|.|||::||||||
Mosquito   328 LTVEVDEHNQLVVARIIAGGMIDRQGLLHPGDVILEVNGVPVTTPEELQGEISVAKESVTLKIGP 392

  Fly   253 NVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDIL 317
            :|:||:||.|.|::||||| || .:|::||||||||||||.|:|:||:||||::|||.|..||||
Mosquito   393 SVEEEMKSARITMAGGQVK-NG-RNLDSGKKLTCYMRALFDYDPNEDNLLPCKEIGLSFLRGDIL 455

  Fly   318 QIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMY 382
            ||||||||||||||: ..|....||||||||||||:|:|.||||:|||||||||||||:|||.:|
Mosquito   456 QIINVKDPNWWQAKH-AGEDGPTGLIPSQELEERRQAYVPPEADFVHKIGICGTRISKKKRKILY 519

  Fly   383 RSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRP 447
            ::..|.|||||:|:||||||:||||:||||||:||:|||||||||||||||.||||:|:|||||.
Mosquito   520 KTKQNSEFDKADLMLYEEVTKMPPFKRKTLVLVGVAGVGRRTLKNRLINSDPDKFGSVLPHTSRQ 584

  Fly   448 KRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNAL 512
            .|.|||:|.:|||.||||||:.:|.|:|||:||||||||||||.||:|||..|:||:|||:|.||
Mosquito   585 PRPLEESGKAYWFTDREEMEQEIRENKFLEFGEHNGNLYGTHLDSIRDVIRQGKMCVLDCSPAAL 649

  Fly   513 KILHNSQELMPFVIFVAAPGMEQLKTIYADRR-ATGSNRNLSFDRQSSIRFSSRRARTLESLASL 576
            |.||||.|.||||:|:|||||||||.:|::|| |:||.|||.||||||||||||||:||||||||
Mosquito   650 KTLHNSPEFMPFVLFIAAPGMEQLKLLYSERRSASGSTRNLHFDRQSSIRFSSRRAKTLESLASL 714

  Fly   577 YEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            ||||||::.||||:.:||||:||.||||||||||:|||||.|.|:|:|||.|||||||||
Mosquito   715 YEDDDLISAVEESALLQRKYDKYLDMVIVNEDFDDTFRQVTEALEQLSHEHQWVPVNWIY 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	14/22 (64%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	56/77 (73%)
		SH3_MPP	287..347	CDD:212796	42/59 (71%)
		Guanylate_kin	408..622	CDD:395500	162/214 (76%)
vari	XP_061511964.1	None