Protein Alignment vari and sdt

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_061507016.1
• Gene: sdt / 1273257
• VectorBaseID: AGAMI1_003603
• Length: 1501
• Species: Anopheles gambiae
• Alignment Length: 783
• Identity: 193/783 - (24%)
• Similarity: 321/783 - (40%)
• Gaps: 237/783 - (30%)

  Fly    10 RQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEP 74
            |:.|:|:..:.|:|:                          ||:..||.:...  :.|..||.|.
Mosquito   799 RRRREDEERIAAQND--------------------------FLRNSLRGSQRL--RALQDNPIEK 835

  Fly    75 QPVPL-----------------------------FLPAHLNN----------------------- 87
            .||.:                             .|..|||.
Mosquito   836 PPVGVDNEAYADDEVVAVAAEKIIGYGELVAALQRLQGHLNKHGLAALAGRVTAAQSLLLGPGIA 900

  Fly    88 ------------------KPIC-------DDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDE 127
                              .|||       .|.:...:.||...:.||..||:......||.|||.
Mosquito   901 RALAVRTAVLERRRPKIPNPICPNAQALAKDCVESLAQSRSQTAIELCDLLSTYEMEGLLLAHDR 965

  Fly   128 IGALYEQR-LKAAGGSTSQLEI----ASQRQTGGYLFT-EDVLNTKMPVETIK------------ 174
            |.:..::. :.:.|||...:.:    ||...|.....| .:.:|.......:|
Mosquito   966 IASTTDRSPIASYGGSPITVPVPLGTASNNTTSNNTTTSNNSINNNTLTSAVKPATVMPSIPNNA 1030

  Fly   175 ------------------MVGLRRD-------------PSKPLGLTVELDEFKQLVVARILAGGV 208
                              .:|:.||             .|:|||.|:. :|.:.:|:.|::.||.
Mosquito  1031 SLVNNNNNNIAKREPMSVPLGVLRDGSQDHIKIIQIEKSSEPLGATIR-NEGEAVVIGRVVRGGA 1094

  Fly   209 IDKQSMLHVGDVILEVNGTPVR--TPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVK 271
            .:|..:||.||.||||||..:|  :.:::...:......||..:.|
Mosquito  1095 AEKSGLLHEGDEILEVNGIEMRGKSVNDVCALLGSMTGTLTFLVVP------------------- 1140

  Fly   272 QNGIASLETGKKL----TCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKN 332
             .|:..:..|..:    ..::||.|.|:|.:|..:|||::|:.|:.||:|.:|:..|||||||..
Mosquito  1141 -AGVPQILPGLGMRDPPVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISRDDPNWWQAYR 1204

  Fly   333 ITAESDKI-GLIPSQELEERR---KAFVAPEA------DYVHKIG-----ICGTRISKRKRKT-- 380
            ...|...: ||||||..:.:|   |..:|.|.      |...|.|     :|..:..|:|:|.
Mosquito  1205 EGEEDQTLAGLIPSQSFQHQRESMKLAIAGEVGLRTRKDINGKAGGGSTLLCARKGRKKKKKASS 1269

  Fly   381 -----MYRSVANCEFDKAELLLYEEVTRMPP--FRRKTLVLIGVSGVGRRTLKNRLINSDVDKFG 438
                 :|.:....:.|..|:|.||||....|  ..::.:||||...:||..|:.||: :|.::|.
Mosquito  1270 EHGYPLYATATADDPDPEEILTYEEVALYYPRASHKRPIVLIGPPNIGRHELRQRLM-ADSERFA 1333

  Fly   439 AVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMC 503
            |.||||||.:|..|..|..|.|:.|::.|..:...:|:|:||:....|||.|::|:.|:.||::|
Mosquito  1334 AAIPHTSRAQREGEVPGQDYHFISRQQFESDILARKFVEHGEYEKAYYGTSLEAIRAVVASGKIC 1398

  Fly   504 ILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRAR 568
            :|:..|.:||:|.:| :|.|:.:.||.|.:|:|:                          .:|.|
Mosquito  1399 VLNLHPQSLKLLRSS-DLKPYTVLVAPPSLEKLR--------------------------QKRIR 1436

  Fly   569 TLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVN 633
            |.|.    |::::|...:..:..::.::...|||:|:|.|.:..:.|::..::.:..|.||||.:
Mosquito  1437 TGEP----YKEEELKEIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPSS 1497

  Fly   634 WIY 636
            |::
Mosquito  1498 WLH 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	9/22 (41%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	28/122 (23%)
		SH3_MPP	287..347	CDD:212796	28/60 (47%)
		Guanylate_kin	408..622	CDD:395500	64/213 (30%)
sdt	XP_061507016.1	None