DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Patj

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	722	Identity:	127/722 - (17%)
Similarity:	227/722 - (31%)	Gaps:	263/722 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LRAHDEIGAL----------YEQRLKAAGGSTSQLEIASQRQTG---GYLFTEDVLNTKMPVETI 173
            |:.:|:|.|:          ::|.:.....:|..|.:...|:.|   |...|... :|.:| ||:
Mouse   179 LKENDQILAINDTPLDQNISHQQAIALLQQATGSLRLVVAREVGHTQGRASTSSA-DTTLP-ETV 241

  Fly   174 -----KMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVR--T 231
                 :.|.|..|.| .||..:...:...:||..|:.||:.|:...|..||.||::.||.|:  |
Mouse   242 CWGHTEEVELINDGS-GLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305

  Fly   232 PDELQVEVSRAKENLTLKIGPNVDEEI-------------------------KSGRYTVSGGQVK 271
            .:::...:.....::.:.:..:...||                         :|...|.|...||
Mouse   306 SEQVAQVLRNCGNSVRMLVARDPVGEIAVTPPTPVSLPVALPAVATRTLDSDRSPFETYSVELVK 370

  Fly   272 QNG----------IASLETGKKLTCYMRALF----TYNPSE----DSLLPCRDIGLP-FKSGDIL 317
            ::|          :.:...|:....|::::.    .|:..:    |.::....:.:. |.:.|::
Mouse   371 KDGQSLGIRIVGYVGTAHPGEASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVV 435

  Fly   318 QIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVA-------------PEADYVHKIGIC 369
            :::.    |..|..::|....|..|..|.......:..||             |||:...:....
Mouse   436 EVLR----NAGQVVHLTLVRRKTSLSASPFEHSSSRETVAEPPKVPERAGSPKPEANLSVEAEEI 496

  Fly   370 GTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLIN--- 431
            |.|:...|..|:.      ..:|.:  :|.|               .|.|.....||:|..|
Mouse   497 GERLDNLKNNTVQ------ALEKPD--VYPE---------------KVPGSPENELKSRWENLLG 538

  Fly   432 -----------------SDVDKFGAVIP-HTSR------------------------------PK 448
                             .::.|:..::| ||.|                              |:
Mouse   539 PDYEVMVATLDAQIADDEELQKYSKLLPIHTLRLGMEVDSFDGHHYISSVAPGGPVDTLNLLQPE 603

  Fly   449 -RALEENGSSYWFMDREE--------------------------------MEEAVRNNEFLEYGE 480
             ..||.||...:...|.|                                ||.|:...|.    :
Mouse   604 DELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTMEPALLEAEV----D 664

  Fly   481 HNGN------------LYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGM 533
            |:.:            |:...:::::        .:.||......||.....|.|....:.
Mouse   665 HSVDVNIEDDDDGELALWSPEVKTVE--------LVKDCKGLGFSILDYQDPLDPTRSVIV---- 717

  Fly   534 EQLKTIYADRRATGSNRNLSFDRQSSI-RFSSRRARTLESL----------------ASLYEDD- 580
              ::::.||..|..|...|..||..|: .||...|...|::                ..|.||:
Mouse   718 --IRSLVADGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEVLKAVPPGVVHLGICKPLVEDEK 780

  Fly   581 ------------------DLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETL-----DQ 622
                              |.|..: .||.:....:.:.|...:.|..||.|..:.::|     |.
Mouse   781 EERFSLHSNNNGDSSEPADAVHEI-HSSLILEAPQGFRDEPYLEELVDEPFLDLGKSLQFQQKDV 844

  Fly   623 MSHEEQW 629
            .|..|.|
Mouse   845 DSSSEAW 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	2/5 (40%)
		PDZ_signaling	173..250	CDD:238492	21/83 (25%)
		SH3_MPP	287..347	CDD:212796	11/68 (16%)
		Guanylate_kin	408..622	CDD:279019	55/350 (16%)
		GuKc	418..622	CDD:214504	54/340 (16%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492	7/38 (18%)
		PDZ_signaling	248..325	CDD:238492	21/77 (27%)
		PDZ_signaling	363..450	CDD:238492	14/90 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488		6/31 (19%)
		PDZ_signaling	572..636	CDD:238492	7/63 (11%)
		PDZ	685..774	CDD:214570	18/102 (18%)
		PDZ_signaling	1072..1163	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219
		PDZ	1242..1327	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453
		MPDZ_u10	<1453..1468	CDD:374710
		PDZ	1469..1554	CDD:214570
		PDZ_signaling	1566..1646	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676
		PDZ_signaling	1707..1792	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900