DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Cask

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_011245733.1	Gene:	Cask / 12361	MGIID:	1309489	Length:	972	Species:	Mus musculus

Alignment Length:	668	Identity:	212/668 - (31%)
Similarity:	331/668 - (49%)	Gaps:	135/668 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TDLSDHDEIFLKGLLRSNSNTPHKELMLN-----PTEPQPVPLFLPAHLNNKPI-----CDDIIR 96
            ||.|:.|..||..:.:..    |...:|:     .|:..|       .:.|.|.     ..:::.
Mouse   367 TDCSEKDLDFLHSVFQDQ----HLHTLLDLYDKINTKSSP-------QIRNPPSDAVQRAKEVLE 420

  Fly    97 KFS--PSRRLESRELAKLLAQPHFRALLRAHDEIG-ALY-EQRLKAAGGSTS-QLEIASQRQTGG 156
            :.|  |... :::||.::|.||||.|||:.||.:. .:| ::.|:.....|| .|...|.....|
Mouse   421 EISCYPENN-DAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANG 484

  Fly   157 YLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVI 221
            .:..|:|..       :::|..:::..:|:|:|::::|....:||||:.||:|.:|..|||||.|
Mouse   485 DMDMENVTR-------VRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEI 542

  Fly   222 LEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNV---------DEEIKSGRYTVSGGQVKQNGI 275
            .|:||..|  :|.::||..:...:.::|.||.|:.         |....|.:...:|.....|.:
Mouse   543 REINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSV 607

  Fly   276 ASLET-----GKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITA 335
            :.|.:     |:::  |:||.|.|:|::|.|:||::.|:.|:.|||:|||:..|.||||.|...:
Mouse   608 SDLPSTTQPKGRQI--YVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENS 670

  Fly   336 ESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKR--KTMYRSVANCEFDKAELLLY 398
            ::...|||||.||:|.|.|.:|.|.....:...| |...|:|:  |..|.:..|..||:.:|:.|
Mouse   671 KNGTAGLIPSPELQEWRVACIAMEKTKQEQQASC-TWFGKKKKQYKDKYLAKHNAVFDQLDLVTY 734

  Fly   399 EEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDR 463
            |||.::|.|:||||||:|..|||||.:||.||....|:|...||||:||.:..||||.:|:|:..
Mouse   735 EEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSH 799

  Fly   464 EEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPN------------------ 510
            ::|.:.:.|||:||||.|...:|||.|::|:.:...|.:.|||..|.
Mouse   800 DQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQGLEKSSGQGWLEAKSQSW 864

  Fly   511 ----------------------ALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLS 553
                                  |||:|..: |..|||:|:|||      ||
Mouse   865 SWSSTSSPWVPHWSSPERRFLLALKVLRTA-EFAPFVVFIAAP------TI-------------- 908

  Fly   554 FDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVE 618
                               ...|.||:.|....:||..:||.|..|||:.|:|.:.|||.|.:.|
Mouse   909 -------------------TPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEE 954

  Fly   619 TLDQMSHEEQWVPVNWIY 636
            .::.:....|||||:|:|
Mouse   955 AVELVCTAPQWVPVSWVY 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	12/22 (55%)
		PDZ_signaling	173..250	CDD:238492	27/78 (35%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:279019	82/253 (32%)
		GuKc	418..622	CDD:214504	75/243 (31%)
Cask	XP_011245733.1	STKc_CASK	8..313	CDD:270996
		L27	354..407	CDD:197794	10/50 (20%)
		L27	412..462	CDD:397114	15/50 (30%)
		PDZ_signaling	494..574	CDD:238492	28/79 (35%)
		SH3_CASK	622..683	CDD:213014	29/60 (48%)
		Guanylate_kin	744..957	CDD:395500	82/252 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920