DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Mpp3

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_446120.1	Gene:	Mpp3 / 114202	RGDID:	620015	Length:	585	Species:	Rattus norvegicus

Alignment Length:	658	Identity:	188/658 - (28%)
Similarity:	307/658 - (46%)	Gaps:	141/658 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 STDLSDHDEI-FLKGLLRSNSNTPHKELM---------------------LNPTEPQ-PVPLFLP 82
            |.|...|:.: .|...||.:||  |:|.|                     |...|.| |.|:...
  Rat     5 SEDSGLHETLALLTSQLRPDSN--HREEMGFLRDVFSEKSLGYLMKIHEKLRYYERQSPTPVLHS 67

  Fly    83 AHLNNKPICDDIIRKF-SPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQL 146
            |    ..:.:|::.:. :.|...:.|||.:||:.||.||:|..||.:
  Rat    68 A----MALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTV------------------ 110

  Fly   147 EIASQRQTGGYL-FTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFK-QLVVARILAGGVI 209
               :|:.....| ...|.::.....|::|:|.|.:: .:|||.|:..||.. .:|||||:.||..
  Rat   111 ---AQKNFDPVLPPLPDNIDEDFEEESVKIVRLVKN-KEPLGATIRRDEHSGAVVVARIMRGGAA 171

  Fly   210 DKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQ 272
            |:..::||||.:.||||..|  :.|||:...:::::.::||||.|...||
  Rat   172 DRSGLVHVGDELREVNGITVLHKRPDEISQILAQSQGSITLKIIPATQEE--------------- 221

  Fly   273 NGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAES 337
                  :..|:...:|||||.|:|.||..:||::.||||:...:|::::..||.|||||.:...:
  Rat   222 ------DRFKESKVFMRALFHYDPREDRAIPCQEAGLPFQQRQVLEVVSQDDPTWWQAKRVGDTN 280

  Fly   338 DKIGLIPSQELEERRKAF-----VAPEADYVHK-----------------------IGICGT-RI 373
            .:.|||||::.:|||.::     ..|....:.|                       .|:..: |:
  Rat   281 LRAGLIPSKQFQERRLSYRRTTGTIPSPQNLRKPLYDQPCDKETCDCDGYFKGHYVAGLRRSFRL 345

  Fly   374 SKRKRKTMYRSV-ANCEFDKAELLLYEEVTR---MPPFRRKTLVLIGVSGVGRRTLKNRLINSDV 434
            ..|:|.|..:.| .....:...||.||||.|   .|..|.:.:||||..|.....||.|::..|.
  Rat   346 GCRERLTGSQEVKVPVGAESQVLLTYEEVARYQHQPGERSRLVVLIGSLGAHLHELKQRVVAEDP 410

  Fly   435 DKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINS 499
            ..||..:|||:||:::.|..|..|.|:.::..|..:::|:|||:|||..|||||.|::|:.|:..
  Rat   411 QHFGVAVPHTTRPRKSHEREGVEYHFVSKQAFEADIQHNKFLEHGEHKENLYGTSLEAIQTVMAK 475

  Fly   500 GRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKT--IYADRRATGSNRNLSFDRQSSIRF 562
            .::|::|..|.||:.| .:.|..|:||||.....|:.||  :..|
  Rat   476 NKVCLVDVEPEALRHL-RTPEFKPYVIFVKPAIQEKRKTPPVSPD-------------------- 519

  Fly   563 SSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEE 627
            |...|..|:.     :..::.|:   ::|:.:.|....|.|:|.:|......|:...::.:|.:.
  Rat   520 SEDPATPLDE-----QQQEMAAS---AAFIDQHYGHLIDTVLVRQDLQSVCSQLRAVIESLSKDT 576

  Fly   628 QWVPVNWI 635
            .|||::|:
  Rat   577 YWVPISWV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	12/22 (55%)
		PDZ_signaling	173..250	CDD:238492	31/79 (39%)
		SH3_MPP	287..347	CDD:212796	28/59 (47%)
		Guanylate_kin	408..622	CDD:279019	64/215 (30%)
		GuKc	418..622	CDD:214504	59/205 (29%)
Mpp3	NP_446120.1	L27	12..64	CDD:197794	12/53 (23%)
		L27	71..121	CDD:197794	16/70 (23%)
		PDZ_signaling	135..215	CDD:238492	32/80 (40%)
		SH3_MPP3	230..291	CDD:212972	28/60 (47%)
		GuKc	395..571	CDD:214504	59/204 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..530		6/44 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740