DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment vari and Card10

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:XP_036014949.1 Gene:Card10 / 105844 MGIID:2146012 Length:1144 Species:Mus musculus


Alignment Length:518 Identity:91/518 - (17%)
Similarity:179/518 - (34%) Gaps:153/518 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 QPVPLFLPAHL----NNKPI--CDDIIRKFSPS----------RRLESRELAKLLAQPHFRALLR 123
            :.:..:.|.|.    ..:|.  |..|:.:..|.          |||.....::|..:...:|..|
Mouse   221 EALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLHREQQLQARGR 285

  Fly   124 AHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGL 188
            |.:|..|..||||:....:..:.:...:....|.|   ::|..|   :...|:.:|         
Mouse   286 ALEEERAGLEQRLREQQQAQERCQRLREDWEAGSL---ELLRLK---DENYMIAMR--------- 335

  Fly   189 TVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPN 253
            ..:|.|.|              ..::|...|:.|.|        |:|:::|||.:|...|     
Mouse   336 LAQLSEEK--------------NSAVLRSRDLQLAV--------DQLKLKVSRLEEECAL----- 373

  Fly   254 VDEEIKSGRYTVSGGQVKQ---NGIASLE----TGKKLTCYMRALFTYNPSEDSLLPCRDIGLPF 311
                ::..|....|.:.|:   :|...|.    ..::||..::.|      ::.|.  :::..|.
Mouse   374 ----LRRARGPPPGAEEKEREPDGADLLSELRAENQRLTASLQEL------QEGLQ--QEMSRPG 426

  Fly   312 KSGDILQIINVKDPNWWQAKNITAE-SDKIGLIPS--QELEERRKAFVAPEAD------------ 361
            .:|....::::.:.:|.:|::...| ..|:..:..  |..||.|..::....|            
Mouse   427 AAGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDKYLQEMEDLRLKHRTLLKDC 491

  Fly   362 --YVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRT 424
              |.|::.....::.:.:::   |..|....|:.:|...:.:.....:|::.             
Mouse   492 DLYKHRMATVLAQLEEIEKE---RDQAIQSRDRIQLQYSQSLIEKDQYRKQV------------- 540

  Fly   425 LKNRLINSDVDKFGAVIPHTSRPKRALE----------------------ENGSSYWFMDREEME 467
               |.:.::.|:....:......|..||                      .|.||.|.:      
Mouse   541 ---RGLEAERDELLTTVTSLEGTKAMLEAQLQRTQGGSCLKACASSHSLCSNLSSTWSL------ 596

  Fly   468 EAVRNNEF---LEYGEHNGNLYGTHLQSIKDVINS----GRMCILDCAPNALKILHNSQELMP 523
                 :||   |...|..|...|:...:.::..:|    .|:.||...|:|..||...:|..|
Mouse   597 -----SEFPSPLGGPEATGEAGGSEPHTSEEATDSEKEINRLSILPFPPSAGSILRRQREEDP 654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 4/22 (18%)
PDZ_signaling 173..250 CDD:238492 16/76 (21%)
SH3_MPP 287..347 CDD:212796 8/62 (13%)
Guanylate_kin 408..622 CDD:279019 26/145 (18%)
GuKc 418..622 CDD:214504 25/135 (19%)
Card10XP_036014949.1 CARD_CARD10_CARMA3 150..235 CDD:260069 2/13 (15%)
Smc <270..>573 CDD:224117 62/375 (17%)
SH3 822..884 CDD:418401
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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