DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment vari and PATJ

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:XP_011538764.1 Gene:PATJ / 10207 HGNCID:28881 Length:1937 Species:Homo sapiens


Alignment Length:845 Identity:145/845 - (17%)
Similarity:267/845 - (31%) Gaps:319/845 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 TDLSDHDEIFLKGLL------RSNSNTPHKELMLNPTEPQPVPLFLP--AHLNNKPICDDIIRKF 98
            :|.|.:.:...||||      .:|.|. |:     |:....|....|  ..|.|:.. :.:|::.
Human    69 SDCSANFDFSRKGLLVFTDGSITNGNV-HR-----PSNNSTVSGLFPWTPKLGNEDF-NSVIQQM 126

  Fly    99 SPSRRLE--------------------SRELAKL-----LAQPHFRA----LLRAHDEIGALYEQ 134
            :..|::|                    |:.|.|:     ..||...|    .|:.:|:|.|:...
Human   127 AQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHT 191

  Fly   135 RLKAAGGSTSQLEIASQRQTGGYL-------------FTEDVLN-TKMP-------VETIKMVGL 178
            .|..  ..:.|..||..:||.|.|             .|...|| |.:|       ||.::::  
Human   192 PLDQ--NISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELI-- 252

  Fly   179 RRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVR--TPDELQVEVSR 241
              :....||..:...:...:||..|:.||:.|:...|..||.||::.||.|:  |.:::...:..
Human   253 --NDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRN 315

  Fly   242 AKENLTLKI----------------------------GPNVDEEIKSGRYTVSGGQVKQNG---- 274
            ...::.:.:                            ||..|..:.. .|.|.  .|:::|    
Human   316 CGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFE-TYNVE--LVRKDGQSLG 377

  Fly   275 ------IASLETGKKLTCYMRALFTYNPS--------EDSLLPCRDIGLP-FKSGDILQIIN--- 321
                  :.:..||:....|::::...:.:        .|.::....:.:. |.:.|:::::.   
Human   378 IRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAG 442

  Fly   322 -------------------------------VKDPNWWQAKNITAES------------------ 337
                                           :|.|..:....:..|:                  
Human   443 QVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKN 507

  Fly   338 ---------DKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKA 393
                     :|:...|..||:.|.:..:.|  ||...:....|:|:                |.|
Human   508 DNIQALEKLEKVPDSPENELKSRWENLLGP--DYEVMVATLDTQIA----------------DDA 554

  Fly   394 ELLLYEEVTRMPPFRRKTLVLIGV---SGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENG 455
            ||..|.::..:...|      :||   |..|...:.:.:....||..|.:.|.    ...||.||
Human   555 ELQKYSKLLPIHTLR------LGVEVDSFDGHHYISSIVSGGPVDTLGLLQPE----DELLEVNG 609

  Fly   456 SSYW--------------------------FMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIK 494
            ...:                          |.|...::|..|....|...|.:.|:   .:.:.:
Human   610 MQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNM---DVNTEE 671

  Fly   495 DVINSGRMC-----------ILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGS 548
            |  :.|.:.           :.||......||.....|.|....:.      ::::.||..|..|
Human   672 D--DDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIV------IRSLVADGVAERS 728

  Fly   549 NRNLSFDRQSSIR----FSSRRARTLESLAS-------------LYEDDDLVATVEESSFVQR-- 594
            ...|..||..|:.    .::..|..:|.|.:             |.||::     |||.::..  
Human   729 GGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNE-----EESCYILHSS 788

  Fly   595 ---------------------------KYEKYFDMVIVNE---DFDETFRQVVETLDQMSHEEQW 629
                                       :.|.||...:|:|   |..::|....:.::|  .:|.|
Human   789 SNEDKTEFSGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQ--SKEAW 851

  Fly   630  629
            Human   852  851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 9/51 (18%)
PDZ_signaling 173..250 CDD:238492 17/78 (22%)
SH3_MPP 287..347 CDD:212796 9/129 (7%)
Guanylate_kin 408..622 CDD:279019 52/302 (17%)
GuKc 418..622 CDD:214504 49/289 (17%)
PATJXP_011538764.1 L27_2 8..65 CDD:117611
PDZ_signaling 135..218 CDD:238492 18/84 (21%)
PDZ_signaling 246..325 CDD:238492 19/82 (23%)
PDZ_signaling 366..450 CDD:238492 9/85 (11%)
PDZ_signaling 570..634 CDD:238492 12/67 (18%)
PDZ 683..772 CDD:214570 17/94 (18%)
PDZ_signaling 1066..1157 CDD:238492
PDZ 1236..1321 CDD:214570
PDZ 1459..1574 CDD:214570
PDZ_signaling 1586..1666 CDD:238492
PDZ_signaling 1729..1814 CDD:238492
PDZ_signaling 1852..1936 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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