DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and LOC100537443

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_003199722.2	Gene:	LOC100537443 / 100537443	-ID:	-	Length:	201	Species:	Danio rerio

Alignment Length:	238	Identity:	47/238 - (19%)
Similarity:	98/238 - (41%)	Gaps:	54/238 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 YEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMD 462
            |:.|.::....|:.::::|..   ...:|:.|:.....|:...:|...:.:
Zfish    10 YQRVLKVESTNRRPVLILGPL---VEPIKDMLLREAPGKYCRCLPEGMKAQ-------------- 57

  Fly   463 REEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIF 527
            ::.:|..|::..|::|...:|:...|.:.|||::......|:||.||:|::.|| :..:.|.|||
Zfish    58 QQAIERGVKDCLFIDYKRRSGHFDVTTVASIKEITEKDCHCLLDIAPHAIERLH-AVSIYPIVIF 121

  Fly   528 VAAPGMEQLK----TIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEE 588
            :.....:|:|    .:|.        |:....:.|..:|                        |.
Zfish   122 IRYRNAKQIKEQKDPVYL--------RDKVSQKHSKEQF------------------------ES 154

  Fly   589 SSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVP 631
            :..:::.|.|||..|:.......|..|::..:||..::..|:|
Zfish   155 AQRIEQDYSKYFTGVVQAGALSNTCTQIMAIVDQEQNKVLWIP 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918
		PDZ_signaling	173..250	CDD:238492
		SH3_MPP	287..347	CDD:212796
		Guanylate_kin	408..622	CDD:279019	41/217 (19%)
		GuKc	418..622	CDD:214504	39/207 (19%)
LOC100537443	XP_003199722.2	NK	34..190	CDD:327404	41/202 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910