Protein Alignment vari and mpp4a

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_009302812.1
• Gene: mpp4a / 100535324
• ZFINID: ZDB-GENE-070912-523
• Length: 627
• Species: Danio rerio
• Alignment Length: 601
• Identity: 166/601 - (27%)
• Similarity: 280/601 - (46%)
• Gaps: 141/601 - (23%)

  Fly   100 PSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYL--FTED 162
            |:...:::||..||..||.:|||.|||.:                     :||..|..|  ..::
Zfish    96 PAPSSDAQELYILLKSPHMQALLSAHDSV---------------------AQRDYGPVLPPLPDN 139

  Fly   163 VLNTKMPVETIKMVGLRRDPSKPLGLTVELDE-FKQLVVARILAGGVIDKQSMLHVGDVILEVNG 226
            :.:.:   |.:::|.|.:: .:|||.|:..|| ...:.:||::.||:.|:..:|:.||.::||||
Zfish   140 LSDNE---EAVRIVCLVKN-KQPLGATIRKDEKTGNIFIARVIHGGLADRSGLLNSGDKLVEVNG 200

  Fly   227 TPVR--TPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMR 289
            ..||  .|:.:...:.|::.|:..|:.||                      ::..|..:.|.|:|
Zfish   201 QKVRGMQPEHVINILVRSQGNILFKVIPN----------------------STQPTNSQATLYVR 243

  Fly   290 ALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPS--------- 345
            |:..|:|.:|..:||.|:|:.|..||:|:|::.:|..||||:.:.:.|...|||||
Zfish   244 AMVDYSPLQDPAIPCPDVGMAFSKGDLLEIVDQRDIRWWQARKLHSASLCCGLIPSTNQFRHKQR 308

  Fly   346 ------------------------QELEERRKA---------FVAPE---ADYVHKIGICGTR-- 372
                                    :|:.::.|.         ||:.|   .:::..:.|.|.|
Zfish   309 ELWWSQPYQAHTCIRPLSADDVGEEEITDKIKCTETDEEDFEFVSEEGENGEHMQGLYIAGFRHS 373

  Fly   373 --------ISKRKRKTMYRSVANCEFDKAELLLYEEVTRM------PPFRRKTLVLIGVSGVGRR 423
                    .||||......|:::|....|.  |||||...      ||   :.:||||.||||..
Zfish   374 LRVWRRKSYSKRKPSCYSCSISSCHNTSAN--LYEEVVHYQRHIDDPP---RLIVLIGPSGVGVN 433

  Fly   424 TLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGT 488
            .|:.|||..:.:.:...:.:|:||:...|:||..|.|:.:|.....|.|::|.||.||||::|||
Zfish   434 ELRRRLIKINPNTYQGPVSYTTRPQNMGEKNGREYHFVTKEVFAYMVVNHKFYEYEEHNGHMYGT 498

  Fly   489 HLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLS 553
            .|.|:|||:::|::|::|..|:.::.:.|.. |.|::|:|..|..|.::....|.....:
Zfish   499 SLDSVKDVLDNGKICVIDIEPHCIQSVRNKM-LKPYIIYVRPPSPEGMRQTRKDPHFLAN----- 557

  Fly   554 FDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVE 618
                   |:..|          .:.|.|.....:.|..::.||.::||.||||||..::...:..
Zfish   558 -------RYIKR----------YFHDKDFEDIEDVSRAMEAKYRQFFDCVIVNEDLQDSCMDLFT 605

  Fly   619 TLDQMSHEEQWVPVNW 634
            .:.....|.||:|.:|
Zfish   606 AIQHAQEEPQWIPASW 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	12/22 (55%)
		PDZ_signaling	173..250	CDD:238492	25/79 (32%)
		SH3_MPP	287..347	CDD:212796	26/92 (28%)
		Guanylate_kin	408..622	CDD:279019	65/213 (31%)
		GuKc	418..622	CDD:214504	61/203 (30%)
mpp4a	XP_009302812.1	L27	24..76	CDD:197794
		L27	84..133	CDD:308467	16/57 (28%)
		PDZ	147..230	CDD:214570	28/105 (27%)
		SH3	241..300	CDD:327375	25/58 (43%)
		Guanylate_kin	419..610	CDD:331880	66/216 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840