DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and caskb

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001135848.1	Gene:	caskb / 100148073	ZFINID:	ZDB-GENE-030131-4473	Length:	921	Species:	Danio rerio

Alignment Length:	629	Identity:	207/629 - (32%)
Similarity:	322/629 - (51%)	Gaps:	102/629 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TDLSDHDEIFLKGLLRSNSNTPHKELMLN-----PTEPQPVPLFLPAHLNNKPICDDIIRKFSP- 100
            ||.|:.|..||..:.:..    |...:|:     .|...|       .:.|.|  .|.:::...
Zfish   361 TDCSEKDLDFLHSVFQDQ----HLHTLLDLYDKINTRSSP-------QIRNPP--SDAVQRAKEV 412

  Fly   101 -------SRRLESRELAKLLAQPHFRALLRAHDEIG-ALY-EQRLKAAGGSTS-QLEIASQRQTG 155
                   ...:|::||.::|.||||.|||:.||.:. .:| :..|:.....|| .|...|.....
Zfish   413 LETISCYPENMEAKELKRILTQPHFMALLQTHDVVAHEVYSDDALRVTPPPTSPYLNGDSPESVN 477

  Fly   156 GYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDV 220
            |.|..|:|..       :::|..:::..:|:|:|:::::....:||||:.||:|.:|..|||||.
Zfish   478 GDLDLENVTR-------VRLVQFQKNTDEPMGITLKMNDLNHCIVARIMHGGMIHRQGTLHVGDE 535

  Fly   221 ILEVNGTPV--RTPDELQVEVSRAKENLTLKIGP-------NVDEEIK--SGRYTVSGGQVKQNG 274
            |.|:||..|  :|.::||..:...:.::|.||.|       :.|:|..  |.:...:|.....:.
Zfish   536 IREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRSQSLSCDKESPDLSRQSPANGHSSVTSS 600

  Fly   275 IASLET-----GKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNIT 334
            |..|.:     |:::  |:||.|.|:|::|.|:||::.|:.|:.|||:|||:..|.||||.|...
Zfish   601 ILDLPSTIQPKGRQI--YVRAQFEYDPAKDELIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLEN 663

  Fly   335 AESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKR--KTMYRSVANCEFDKAELLL 397
            .::...|||||.||:|.|.|.:|.|.....:...| |...|:|:  |..|.:..|     |:|:.
Zfish   664 TKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASC-TWFGKKKKQYKDKYLAKHN-----ADLVT 722

  Fly   398 YEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMD 462
            ||||.::|.|:||||||:|..|||||.:||.||....|||...||||:||.:..||||.:|:|:.
Zfish   723 YEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLIAKHPDKFAYPIPHTTRPPKKDEENGKNYFFVS 787

  Fly   463 REEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIF 527
            .::|.:.:.|||:||||.|...:|||.|::|:.:.....:.|||..|.|||:|..: |..|:|:|
Zfish   788 HDQMMQDISNNEYLEYGSHEDAMYGTRLETIRKIHELNMVAILDVEPQALKVLRTA-EFSPYVVF 851

  Fly   528 VAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFV 592
            :|||.:....|                                       ||:.|....:||..:
Zfish   852 IAAPTITPAMT---------------------------------------EDESLQRLQKESEAL 877

  Fly   593 QRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            |..|..|||..|:|.:.|:|.|.:.|.::.:....|||||:|:|
Zfish   878 QHSYAHYFDQTIINNEIDDTIRLLEEAVELVCSTAQWVPVSWVY 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	13/22 (59%)
		PDZ_signaling	173..250	CDD:238492	26/78 (33%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:279019	77/213 (36%)
		GuKc	418..622	CDD:214504	70/203 (34%)
caskb	NP_001135848.1	STKc_CASK	8..307	CDD:270996
		S_TKc	12..276	CDD:214567
		L27	348..>390	CDD:197794	8/32 (25%)
		L27	406..452	CDD:280918	13/45 (29%)
		PDZ_signaling	488..568	CDD:238492	27/79 (34%)
		SH3_CASK	616..677	CDD:213014	29/60 (48%)
		Guanylate_kin	733..906	CDD:279019	77/212 (36%)
		GuKc	743..909	CDD:214504	70/205 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920