Protein Alignment vari and mpp2

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_012826953.1
• Gene: mpp2 / 100124723
• XenbaseID: XB-GENE-961053
• Length: 559
• Species: Xenopus tropicalis
• Alignment Length: 635
• Identity: 235/635 - (37%)
• Similarity: 360/635 - (56%)
• Gaps: 103/635 - (16%)

  Fly    12 ARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRS-NSNTPHKELMLNPTEPQ 75
            |.:.::...|....::|..|...:         ||.|.|||:|::.| .::...:|:.|.....
 Frog    18 AEESEIHRKAMQRVLHGLSDLPAS---------SDLDLIFLQGIMESPKAHECMEEIRLEAVRE- 72

  Fly    76 PVPLFLPAHLNNKPICDDIIRKFSPSRRLE--SRELAKLLAQPHFRALLRAHDEIGAL-YEQRLK 137
                      ||..:..:|::..:..|...  :.||..:|.:|||::||:.||.:.:. ||....
 Frog    73 ----------NNLQLVQEILQDMAGVRDPSGVAAELQGILQEPHFQSLLQTHDSVASKNYETPPP 127

  Fly   138 AAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVAR 202
            :.                  :....:.|..:|.:.::|||:|:...:.||:|..: |..:||:||
 Frog   128 SP------------------MLDPTLSNQPVPPDAVRMVGIRKSAGEHLGVTFRV-EGGELVIAR 173

  Fly   203 ILAGGVIDKQSMLHVGDVILEVNGTPVRT-PDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVS 266
            ||.|||||:|.:|||||||.||||..|.: |..||..:..|..::.|||.|:..|:
 Frog   174 ILHGGVIDQQGLLHVGDVIREVNGREVGSDPQALQEMLREASGSVVLKILPSYQEQ--------- 229

  Fly   267 GGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQA- 330
             ..::|             .:::..|:|:||.|||:||::.|||||:||:|||:|.:|||||||
 Frog   230 -HPLRQ-------------VFVKCHFSYDPSSDSLIPCKEAGLPFKAGDLLQIVNQEDPNWWQAC 280

  Fly   331 --KNITAESDKIGLIPSQELEERRKAFVAPEADYV-HKIGICGTRISKRKRKTMYRSVANCEFDK 392
              |..||     ||||||.|||:|||||..:.::. :...:||:...|:|::.||.:..|.|||:
 Frog   281 LVKGGTA-----GLIPSQLLEEKRKAFVKRDGEFTPNSSALCGSIGGKKKKRIMYVTTKNAEFDR 340

  Fly   393 AELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSS 457
            .|||:||||.||||||||||:|||..|||||:|||:|:.||..::|..||:|||.::..|.:|.|
 Frog   341 HELLIYEEVARMPPFRRKTLILIGAQGVGRRSLKNKLLTSDPSRYGTTIPYTSRKRKEGEWDGQS 405

  Fly   458 YWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELM 522
            |.|:.|.|||:.::...:||:||:.||||||.:.||::|:.||:||:||..|.|:|:|..: |.:
 Frog   406 YSFVTRAEMEQDIKAGRYLEHGEYEGNLYGTKISSIQEVVASGKMCVLDVNPQAVKVLRTA-EFV 469

  Fly   523 PFVIFVAAPGMEQLKTIYADRRATG-SNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATV 586
            |:|:||.||..:.||:........| :|:.|:                         |.:|:..|
 Frog   470 PYVVFVGAPDFQTLKSNNLSAVEVGITNKQLT-------------------------DAELLRIV 509

  Fly   587 EESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            |||..:|:.|..|||:.:||.|.|:||:::...|::::.|.|||||:|:|
 Frog   510 EESERLQQAYGHYFDLTLVNYDLDQTFQELQVALEKLNSEPQWVPVSWVY 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	10/24 (42%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	39/78 (50%)
		SH3_MPP	287..347	CDD:212796	35/62 (56%)
		Guanylate_kin	408..622	CDD:395500	87/214 (41%)
mpp2	XP_012826953.1	L27	75..126	CDD:460717	14/50 (28%)
		PDZ_MPP6-MPP2-like	146..224	CDD:467268	39/78 (50%)
		SH3	236..294	CDD:473055	35/62 (56%)
		GuKc	366..547	CDD:214504	79/206 (38%)