DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and dlg4

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_009300293.1	Gene:	dlg4 / 100000823	-ID:	-	Length:	805	Species:	Danio rerio

Alignment Length:	647	Identity:	161/647 - (24%)
Similarity:	277/647 - (42%)	Gaps:	163/647 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DKVELLARNNKVNGEDDTSDNA--AFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPV 77
            ||:  ||.|| |..||...::|  |.:|:.::     ::|:                   ..:|.
Zfish   287 DKI--LAVNN-VCLEDVMHEDAVGALKNTAEV-----VYLR-------------------VAKPN 324

  Fly    78 PLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGS 142
            .|:|..:.|.    .|:...:||       .|...|..|:|         :.:.|.|.|.....|
Zfish   325 NLYLTNNYNP----PDLTSTYSP-------HLDTDLGHPNF---------LASDYPQALTPTSPS 369

  Fly   143 TSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDP--------SKPLGLT-VELDEFKQL 198
            .....:      .|.|..:|               |.|||        |..||.. |..::.:.:
Zfish   370 RFSPVL------HGLLGDDD---------------LPRDPRRVVIHRGSTGLGFNIVGGEDGEGI 413

  Fly   199 VVARILAGGVIDKQSMLHVGDVILEVNGTPVR--TPDELQVEVSRAKENLTLKIGPNVDEEIKSG 261
            .::.|||||..|....|..||.||.|||..:|  |.::....:..|.:.:|: |.....||.  .
Zfish   414 FISFILAGGPADLSGELRKGDQILSVNGVDLRAATHEQAAAALKNAGQTVTI-IAQYRPEEY--S 475

  Fly   262 RYTVSGGQVKQ--------NGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQ 318
            |:......:::        :|..:|.:..|...|:||||.|:.:.|.....:.:|  |:.||:|.
Zfish   476 RFEAKIHDLREQLMNSSMGSGTTTLRSNPKRGFYIRALFDYDKTADCGFLSQAVG--FRFGDVLH 538

  Fly   319 IINVKDPNWWQAKNITAESD--KIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTM 381
            :::..|..||||..::.:.|  ::|.|||:...||::                .||:..::|...
Zfish   539 VLDCGDEEWWQACRVSPQGDEEEVGFIPSKRRVERKE----------------WTRLKSKERDRS 587

  Fly   382 YRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDV-----DKFGAVI 441
            ..|:.: :..:..:..||.|.::.....:.::::|       .:|:| :|.|:     ||||:.:
Zfish   588 RDSIGS-QGREEPVRSYETVAQVEVHYARPIIILG-------PVKDR-VNDDLLSEFPDKFGSCV 643

  Fly   442 PHTSRPKRALEENGSSYWFM-DREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVI-NSGRMCI 504
            |||:||||..|.:|..|.|: .||:||:.::|:.|:|.|::|.:||||.:||:::|. ..|:.||
Zfish   644 PHTTRPKREYEVDGRDYHFVSSREQMEKDIQNHRFIEAGQYNSHLYGTSVQSVREVAEQQGKHCI 708

  Fly   505 LDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRART 569
            ||.:.||::.|..:| |.|..|||....:|.:..|                   :.|.:..:||.
Zfish   709 LDVSANAVRRLQAAQ-LHPIAIFVRPKSLENVLEI-------------------NTRLTEEQARK 753

  Fly   570 LESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVP 631
            ....|...|.|.|               :.|..::..:.|:|.:.:|...:::.|....|:|
Zfish   754 GMDRAIKLEQDFL---------------ECFSAIVEGDSFEEVYHKVKTVIEEQSGPYIWIP 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	4/22 (18%)
		PDZ_signaling	173..250	CDD:238492	26/87 (30%)
		SH3_MPP	287..347	CDD:212796	22/61 (36%)
		Guanylate_kin	408..622	CDD:279019	63/220 (29%)
		GuKc	418..622	CDD:214504	62/210 (30%)
dlg4	XP_009300293.1	MAGUK_N_PEST	39..141	CDD:287565
		PDZ_signaling	142..226	CDD:238492
		PDZ	234..323	CDD:214570	13/62 (21%)
		PDZ_assoc	334..389	CDD:287558	17/95 (18%)
		DegQ	<372..465	CDD:223343	28/113 (25%)
		PDZ	388..471	CDD:214570	24/83 (29%)
		SH3	507..572	CDD:302595	22/66 (33%)
		Guanylate_kin	613..792	CDD:279019	63/221 (29%)
		GuKc	624..792	CDD:214504	62/203 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810