Protein Alignment cad and NKX6-2

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 65/280 - (23%)
• Similarity: 95/280 - (33%)
• Gaps: 118/280 - (42%)

  Fly   134 APQLNETNSSIGVG-------------GAGGGGGVGG--------ATDG---GPGSAPPNHQQHI 174
            ||.|....:.:.:|             ||.|||.:||        ::.|   ||.:|       :
Human    42 APALGGLGAQLPLGTPHGISDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAA-------V 99

  Fly   175 AEGLPSPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSV 239
            |.|.|.|                        ||.
Human   100 ARGYPKP------------------------LAE------------------------------- 109

  Fly   240 SNNNRTSPSKPPYFDWMKKPAYPAQPQPDLSSSPNL---EDLSDLLDASGKTRTKDKYRVVYTDF 301
                  .|.:||.|       :|...|......|.|   .....:||..||   |...|..::..
Human   110 ------LPGRPPIF-------WPGVVQGAPWRDPRLAGPAPAGGVLDKDGK---KKHSRPTFSGQ 158

  Fly   302 QRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQN---------KKGSDPN 357
            |...|||.:..::|:....::.||.:|.::|.|||:||||||.|.||::         |:.||..
Human   159 QIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAE 223

  Fly   358 VMGVGVQHA----DYSQLLD 373
            .:.||...|    :|::.||
Human   224 KLKVGGSDAEDDDEYNRPLD 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	20/54 (37%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		18/127 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		7/25 (28%)
		Homeodomain	147..205	CDD:459649	22/60 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		9/34 (26%)