Protein Alignment cad and nkx2.1

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_571851.1
• Gene: nkx2.1 / 81883
• ZFINID: ZDB-GENE-010404-1
• Length: 346
• Species: Danio rerio
• Alignment Length: 232
• Identity: 57/232 - (24%)
• Similarity: 95/232 - (40%)
• Gaps: 59/232 - (25%)

  Fly   165 SAPPNHQQHIAEGLPSPPITVSGSEISSP---------------GAP---------TSASSPHHH 205
            |..|.|         :.|.:|  |:|.||               |||         |.|:...||
Zfish     2 SMSPKH---------TTPFSV--SDILSPLEESYKKVSMEGNNLGAPLASYRQPQVTQAAMQQHH 55

  Fly   206 LAH--------HLSAVANN-----------NNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPP 251
            :.|        |::|...:           |.|..|.::.|:..:....:.:.::...|:|.  |
Zfish    56 MGHNGTVPAAYHMTAAGVSQLSHTAMGGYCNGNLGNMSDLPAYQDGMRGSTTATSWYGTNPD--P 118

  Fly   252 YFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGK-TRT-KDKYRVVYTDFQRLELEKEYCTSR 314
            .|..:.: ...:....::.|...|..|:|:....|. |.| :.|.||:::..|..|||:.:...:
Zfish   119 RFSTISR-FMGSSSGMNMGSMSTLSSLADVGKGMGPLTSTPRRKRRVLFSQAQVYELERRFKQQK 182

  Fly   315 YITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNK 351
            |::...:..||..:.|:..||||||||.|.|.::|.|
Zfish   183 YLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAK 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	21/54 (39%)
nkx2.1	NP_571851.1	Homeodomain	160..216	CDD:459649	21/55 (38%)