Protein Alignment cad and NANOG

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_079141.2
• Gene: NANOG / 79923
• HGNCID: 20857
• Length: 305
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 59/256 - (23%)
• Similarity: 84/256 - (32%)
• Gaps: 86/256 - (33%)

  Fly   163 PGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAP-TSASSPHHHLAHHLSAVANNNNNNNNNNNS 226
            |.|.|........|..|.|  .:.|.|.:.|... :||..||
Human     8 PQSLPCFEASDCKESSPMP--VICGPEENYPSLQMSSAEMPH----------------------- 47

  Fly   227 PSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRT- 290
                            ..|....|...|.:      .|..||.|:||           .||..|
Human    48 ----------------TETVSPLPSSMDLL------IQDSPDSSTSP-----------KGKQPTS 79

  Fly   291 ---------------KDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQ 340
                           |.|.|.|::..|...|...:...:|:::::..||:..|:||.:|||.|||
Human    80 AEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQ 144

  Fly   341 NRRAKERKQNKKGSDPNVMGVGVQHADYSQLLDAKAKLEPGLHLSHSLAHSMNPMAAMNIP 401
            |:|.|.::..|.....|..||..:         |.|...|.|:.|:.....:||..  |:|
Human   145 NQRMKSKRWQKNNWPKNSNGVTQK---------ASAPTYPSLYSSYHQGCLVNPTG--NLP 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	20/54 (37%)
NANOG	NP_079141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		25/145 (17%)
		COG5576	74..191	CDD:227863	35/125 (28%)
		Homeodomain	97..152	CDD:459649	20/54 (37%)
		Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768	122..151		14/28 (50%)
		8 X repeats starting with a Trp in each unit	196..240
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305