Protein Alignment cad and ZFHX4

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_078997.4
• Gene: ZFHX4 / 79776
• HGNCID: 30939
• Length: 3616
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 74/393 - (18%)
• Similarity: 132/393 - (33%)
• Gaps: 135/393 - (34%)

  Fly    99 PTSAHQ-------LMQQHHHHHAHASSSSASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVG 156
            |..:|:       |.:......:|..|...:.|..:....|.:|.:
Human  2670 PAQSHKRCPFCRALFKAKSALESHIRSRHWNEGKQAGYSLPPSPLI------------------- 2715

  Fly   157 GATDGGPGSAPPNHQQHIAEGLPSPPIT--------VSGSEISSPGAPTSASSPHHHLA------ 207
             :|:.| |.:|   |::|....||.|:|        ...|.:|:|.:.|:..||.:.|:
Human  2716 -STEDG-GESP---QKYIYFDYPSLPLTKIDLSSENELASTVSTPVSKTAELSPKNLLSPSSFKA 2775

  Fly   208 ------HHLSAVANNNNNNNNNNN-----------SPSTHNNNNNNNSVSNNNRT-------SPS 248
                  .:|:|.......:.|..:           |.:|..:..|....|....:       ||.
Human  2776 ECSEDVENLNAPPAEAGYDQNKTDFDETSSINTAISDATTGDEGNTEMESTTGSSGDVKPALSPK 2840

  Fly   249 KPPYFDWMKKPAYPAQPQPDLS--------SSPNL-------------------------EDLSD 280
            :|...|.:.|||  ..|..::.        :||::                         .:.|.
Human  2841 EPKTLDTLPKPA--TTPTTEVCDDKFLFSLTSPSIHFNDKDGDHDQSFYITDDPDDNADRSETSS 2903

  Fly   281 LLDASG----------KTRTKD-----KYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSL 330
            :.|.|.          |:::.|     ::|...::.|...|:..:...|..|::....|...:.|
Human  2904 IADPSSPNPFGSSNPFKSKSNDRPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGL 2968

  Fly   331 SERQVKIWFQNRRAKERK-------------QNKKGSDPNVMGVGVQHADYSQLLDAKAKLEPGL 382
            .:|.|::||||.||||:|             ...:|:.|.....||:   ||..|..:..:....
Human  2969 PKRVVQVWFQNARAKEKKFKINIGKPFMINQGGTEGTKPECTLCGVK---YSARLSIRDHIFSKQ 3030

  Fly   383 HLS 385
            |:|
Human  3031 HIS 3033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	17/54 (31%)
ZFHX4	NP_078997.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..480
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..545
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..611
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	646..667	CDD:275368
		C2H2 Zn finger	701..718	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1299..1369
		C2H2 Zn finger	1399..1419	CDD:275371
		C2H2 Zn finger	1427..1444	CDD:275371
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1474..1525
		C2H2 Zn finger	1543..1567	CDD:275368
		C2H2 Zn finger	1595..1613	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1806..1836
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1854..1903
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1993..2069
		HOX	2130..2185	CDD:197696
		Homeodomain	2227..2283	CDD:459649
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2334..2356
		PHA02682	2350..>2506	CDD:177464
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2373..2476
		COG5576	2542..>2664	CDD:227863
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2552..2609
		Homeodomain	2606..2662	CDD:459649
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2809..2856		11/48 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2874..2930		5/55 (9%)
		Homeodomain	2930..2986	CDD:459649	17/55 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3141..3221
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3330..3386
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3492..3511
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3560..3583