| Sequence 1: | NP_001260641.1 | Gene: | cad / 35341 | FlyBaseID: | FBgn0000251 | Length: | 445 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_082292.1 | Gene: | Nanog / 71950 | MGIID: | 1919200 | Length: | 305 | Species: | Mus musculus |
| Alignment Length: | 248 | Identity: | 55/248 - (22%) |
|---|---|---|---|
| Similarity: | 93/248 - (37%) | Gaps: | 78/248 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 177 GLPSPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNN---NS 238
Fly 239 VSNNNRTSPSKPPYFDWMKKPA---YPAQPQPDLSSSPNLEDLSDLLDASGKTR------TKDKY 294
Fly 295 RVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNK-------- 351
Fly 352 ----KGSDPNVMGVGVQHADYSQLLDAKAKLEPGLHLSHSLAHSMNPMAAMNI 400 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| cad | NP_001260641.1 | Homeodomain | 293..348 | CDD:459649 | 20/54 (37%) |
| Nanog | NP_082292.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..30 | 10/52 (19%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 46..95 | 12/55 (22%) | |||
| Sufficient for interaction with SALL4. /evidence=ECO:0000269|PubMed:16840789 | 96..155 | 21/58 (36%) | |||
| Homeodomain | 98..153 | CDD:459649 | 20/54 (37%) | ||
| Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H9S0 | 123..152 | 14/28 (50%) | |||
| PTZ00395 | <190..>250 | CDD:185594 | 1/8 (13%) | ||
| 10 X repeats starting with a Trp in each unit | 198..247 | 55/248 (22%) | |||
| Sufficient for transactivation activity | 198..247 | 55/248 (22%) | |||
| Sufficient for strong transactivation activity | 248..305 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||