Protein Alignment cad and nkx6.3

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_001159612.1
• Gene: nkx6.3 / 558978
• ZFINID: ZDB-GENE-070810-7
• Length: 272
• Species: Danio rerio
• Alignment Length: 362
• Identity: 78/362 - (21%)
• Similarity: 121/362 - (33%)
• Gaps: 118/362 - (32%)

  Fly    64 MYYNSHHMFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSS 128
            ::.||.:.|.|...|...::..|     ::|.:..|.:.:..:|....|    ..|...|.|..|
Zfish    10 LFNNSLNQFPSDIKAPVCQYSIP-----NSFYKLGPANINSQLQAGTPH----GISDILSRSMVS 65

  Fly   129 GGAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGL---PSPPITVSGSEI 190
            |  ||.|.|        :.|....||. |.|...||..  .::.:...||   |.|.:..:|.:
Zfish    66 G--PGTPAL--------LSGYPSMGGF-GTTVPSPGVY--YNRDYTPSGLSTFPKPVVECAGMK- 116

  Fly   191 SSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDW 255
               |..:|......:..........||..:|..|              |.....|.|:
Zfish   117 ---GKSSSCWVDGGYEWRGARQQCGNNMGHNPEN--------------VGKKKHTRPT------- 157

  Fly   256 MKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRR 320
                                                      ::..|...|||.:..::|:....
Zfish   158 ------------------------------------------FSGHQIFALEKTFEQTKYLAGPE 180

  Fly   321 KSELAQTLSLSERQVKIWFQNRRAKERKQNKKGSDPN--------VMGVG----VQHADYSQLLD 373
            ::.||.:|.::|.|||:||||||.|.||  |..::|:        ..|.|    |:..:|::.||
Zfish   181 RARLAYSLGMTESQVKVWFQNRRTKWRK--KSATEPSSTQTSRGESAGDGSENEVEDEEYNKPLD 243

  Fly   374 AKAKLEPGLHL--SHSLAHSMNPMAAMNIPAMRLHPH 408
            .....|....|  .|..|.|:          :||.||
Zfish   244 PDTDDEKIRQLLRKHRRAFSV----------LRLGPH 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	19/54 (35%)
nkx6.3	NP_001159612.1	Homeodomain	150..208	CDD:459649	21/106 (20%)