DRSC/TRiP Functional Genomics Resources

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Protein Alignment cad and pitx2

DIOPT Version :10

Sequence 1:NP_001260641.1 Gene:cad / 35341 FlyBaseID:FBgn0000251 Length:445 Species:Drosophila melanogaster
Sequence 2:NP_001017227.1 Gene:pitx2 / 549981 XenbaseID:XB-GENE-482492 Length:345 Species:Xenopus tropicalis


Alignment Length:281 Identity:63/281 - (22%)
Similarity:102/281 - (36%) Gaps:61/281 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 PNHQQHIAEGLPSPPITVSGSEISSPGAPTSASSPH-HHLAHHLSAVANNNNNNNNNNNSPSTHN 231
            |.|..|:.           ||:::      :|||.| ||...|.....::..:::..:..|....
 Frog     7 PLHLDHLV-----------GSKLA------TASSHHQHHHQQHQQHQHHHQQHHHQQHQQPQPQA 54

  Fly   232 NNNNNNSVSNNNRTSPSKPPY-FDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYR 295
            ....:.:.|...|:...|... ...:...:.|.....|.|.....||.|  .|...|.:.:.:.|
 Frog    55 VTLVSMASSLGQRSGECKARLEVHTISDTSSPEAADKDKSHQSKNEDSS--TDDPSKKKRQRRQR 117

  Fly   296 VVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQN--------KK 352
            ..:|..|..|||..:..:||..:..:.|:|...:|:|.:|::||:|||||.||:.        |.
 Frog   118 THFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKN 182

  Fly   353 GSDPNVMGVGVQHAD----YSQ-------LLDAKAKLE---------------------PGLHLS 385
            |..|...|:...:.|    ||.       |..|....:                     |....|
 Frog   183 GFGPQFNGLMQPYDDMYPSYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSSPNSISS 247

  Fly   386 HSLAHSMNPMAAMNIPAMRLH 406
            .|::..|.|.|...:|...|:
 Frog   248 MSMSSGMVPSAVTGVPGSGLN 268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cadNP_001260641.1 Homeodomain 293..348 CDD:459649 20/54 (37%)
pitx2NP_001017227.1 Homeodomain 114..170 CDD:459649 20/55 (36%)
OAR 303..320 CDD:461067
Blue background indicates that the domain is not in the aligned region.

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