Protein Alignment cad and NKX3-1

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_006158.2
• Gene: NKX3-1 / 4824
• HGNCID: 7838
• Length: 234
• Species: Homo sapiens
• Alignment Length: 230
• Identity: 51/230 - (22%)
• Similarity: 78/230 - (33%)
• Gaps: 88/230 - (38%)

  Fly   124 GSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVGGATD---GGPGSAPPNHQQHIAEGLPSPPITV 185
            |:...||...:.:..:..........||....|...|   .||.:||..     ||.|
Human    38 GAQRQGGRTSSQRQRDPEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEE-----AETL------- 90

  Fly   186 SGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKP 250
                        :.:.|..||..:|                             .::..||.:.|
Human    91 ------------AETEPERHLGSYL-----------------------------LDSENTSGALP 114

  Fly   251 PYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRY 315
                  :.|..|.|||                         .:.|..::..|.:|||:::...:|
Human   115 ------RLPQTPKQPQ-------------------------KRSRAAFSHTQVIELERKFSHQKY 148

  Fly   316 ITIRRKSELAQTLSLSERQVKIWFQNRRAK-ERKQ 349
            ::...::.||:.|.|:|.||||||||||.| :|||
Human   149 LSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQ 183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	22/55 (40%)
NKX3-1	NP_006158.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		27/176 (15%)
		Homeodomain	125..181	CDD:459649	22/55 (40%)