Protein Alignment cad and E5

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 112/519 - (21%)
• Similarity: 163/519 - (31%)
• Gaps: 151/519 - (29%)

  Fly    28 QPWNWTPNYHHTPPNHQFLGDVDSSHAAHHAAAAHQMYYNSHHMFHSAAAASAGEWHSPASSTAD 92
            |.:|..|    ..|...|:....|..|:..:.:|           .|..:|||......|.| .|
  Fly     7 QTFNMLP----MAPTSPFVSSSSSVAASSTSVSA-----------SSTVSASASSKPKLAFS-ID 55

  Fly    93 NFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGG-----------------APGAPQLNET 140
            :.|....|.:..|...........|.|.||..::::.|                 ...:||.:..
  Fly    56 SIVGESSTRSAPLRVSVISSPPPRSESPASPTNTNNSGRRTPRGYIYCRRRDSLDRSRSPQRSPV 120

  Fly   141 NSSIGVGGAGGGGGVGG--ATDGGPGSA---PPNHQQHIAEGLPSPPITVSGSEISSP------- 193
            :.|.....|||.....|  |..|.|.|.   ||...:.:.  ||:|.:.:.|:. :||
  Fly   121 SRSPSPPNAGGNPAAAGNTAKSGDPSSGTGNPPTLIRPLP--LPAPNLALIGNR-TSPNAMAVRM 182

  Fly   194 -GAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMK 257
             |.|...|.|...||......|            ...|::..............|:.||:.....
  Fly   183 AGPPHPPSQPPPFLAAQFQMAA------------ALAHHHQQQQQQQQQQLPPVPTGPPHGPHPH 235

  Fly   258 KP------------AYPAQPQP----DLSSSPNLEDLSD-------LLDASGKT----------- 288
            .|            .:|..|.|    ...|:|:|  :.|       ||...|:.
  Fly   236 LPPGQIPLGIFPGGPHPGHPPPHGHHPFGSAPHL--IRDSYPLYPWLLSRHGRIFPRFPGNFLFQ 298

  Fly   289 --RTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNK 351
              |...:.|..::..|.|:||..:..:.|:....:.:|||.|||:|.|||:||||||.|.::..:
  Fly   299 PFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQ 363

  Fly   352 KGSD---------------------PNVMGVGVQHA-------------------------DYSQ 370
            :|.|                     .:....|.||:                         ||..
  Fly   364 EGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQHSYEDAEDPEDEDEIEEDDEDEVIDMDDYGS 428

  Fly   371 LLDAKAKLEPGLHLSHSLAHSMNPMAAMNI-PAMRLHPHLAAHSHSLAAVAAHSHQLQQQHSAQ 433
            .:||:............||.........|. .|..|.|.   ..|.|  :..|...|||||..|
  Fly   429 EMDAEEHQRLREQFQQQLAQHQQQFMQQNAGEAATLSPQ---QQHQL--LQQHQQHLQQQHHQQ 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	23/54 (43%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	23/55 (42%)