Protein Alignment cad and NANOGP8

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_001342210.1
• Gene: NANOGP8 / 388112
• HGNCID: 23106
• Length: 305
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 56/241 - (23%)
• Similarity: 89/241 - (36%)
• Gaps: 56/241 - (23%)

  Fly   163 PGSAPPNHQQHIAEGLPSPPITVSGSEISSPGAP-TSASSPHHHLAHHL-SAVANNNNNNNNNNN 225
            |.|.|...:....|..|.|  .:.|.|.:.|... :||..||......| |::.....::.:::.
Human     8 PQSLPCFEESDCKESSPMP--VICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSST 70

  Fly   226 SPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRT 290
            ||......:..|||:......|.|
Human    71 SPKGKQPTSAENSVAKKEDKVPVK----------------------------------------- 94

  Fly   291 KDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKKGSD 355
            |.|.|.|::..|...|...:...:|:::::..||:..|:||.:|||.||||:|.|.::..|....
Human    95 KQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWP 159

  Fly   356 PNVMGVGVQHADYSQLLDAKAKLEPGLHLSHSLAHSMNPMAAMNIP 401
            .|..||..:         |.|...|.|:.|:.....:||..  |:|
Human   160 KNSNGVTQK---------ASAPTYPSLYSSYHQGCLVNPTG--NLP 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	20/54 (37%)
NANOGP8	NP_001342210.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		22/130 (17%)
		Homeodomain	97..152	CDD:459649	20/54 (37%)
		8 X repeats starting with a Trp in each unit	196..240
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305