Protein Alignment cad and HOXD11

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_067015.2
• Gene: HOXD11 / 3237
• HGNCID: 5134
• Length: 338
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 74/284 - (26%)
• Similarity: 103/284 - (36%)
• Gaps: 94/284 - (33%)

  Fly   122 SSGSSSSGGAPGAPQLNETNSSIGVGGAGGGGGVGG-------ATDGGPGSAPPNHQQHIAEGLP 179
            |:|..||||.||                |||||.||       |......:|.........|.||
Human    83 SAGGGSSGGGPG----------------GGGGGAGGYAPYYAAAAAAAAAAAAAEEAAMQRELLP 131

  Fly   180 ----SPPITVSGSE--ISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNS 238
                .|.:.....|  .::||.|   ..|....::..|||       ..|...|         ..
Human   132 PAGRRPDVLFKAPEPVCAAPGPP---HGPAGAASNFYSAV-------GRNGILP---------QG 177

  Fly   239 VSNNNRTSPSKPPYFDWMKKPAYPAQPQPD--------------------LSSSPNLE------- 276
            .......:|..|  |...:.|..||.|||:                    ..::|..|
Human   178 FDQFYEAAPGPP--FAGPQPPPPPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAEG 240

  Fly   277 --------------DLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYITIRRKSELAQT 327
                          :.|....|..::|.|   |..||.:|..|||:|:..:.||...::.:|::.
Human   241 SGGDGEGPPGEAGAEKSSSAVAPQRSRKK---RCPYTKYQIRELEREFFFNVYINKEKRLQLSRM 302

  Fly   328 LSLSERQVKIWFQNRRAKERKQNK 351
            |:|::|||||||||||.||:|.|:
Human   303 LNLTDRQVKIWFQNRRMKEKKLNR 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	26/54 (48%)
HOXD11	NP_067015.2	DUF3528	26..185	CDD:432284	31/136 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..270		15/95 (16%)
		Homeodomain	267..323	CDD:459649	28/58 (48%)