DRSC/TRiP Functional Genomics Resources

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Protein Alignment cad and HOXD8

DIOPT Version :10

Sequence 1:NP_001260641.1 Gene:cad / 35341 FlyBaseID:FBgn0000251 Length:445 Species:Drosophila melanogaster
Sequence 2:NP_062458.1 Gene:HOXD8 / 3234 HGNCID:5139 Length:290 Species:Homo sapiens


Alignment Length:375 Identity:102/375 - (27%)
Similarity:140/375 - (37%) Gaps:132/375 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVSHYYNTLPYTQKHSAANLAYASAAGQPWNWTPNYHHTPPNHQFLGDVDSSHAAHHAAAAHQMY 65
            |.|::.|  |...|:.|| .|.|:|||:..|  |.|:    :..|..:|...|||  ||||.|:|
Human     1 MSSYFVN--PLYSKYKAA-AAAAAAAGEAIN--PTYY----DCHFAPEVGGRHAA--AAAALQLY 54

  Fly    66 YNSHHMFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGG 130
            .||          :||..|:|..:                       |||...|...||:...|.
Human    55 GNS----------AAGFPHAPPQA-----------------------HAHPHPSPPPSGTGCGGR 86

  Fly   131 APGAPQLNETNSSIGVGGAG------GGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSE 189
            .                |.|      |||....|....|  .||.|..      |.||....|. 
Human    87 E----------------GRGQEYFHPGGGSPAAAYQAAP--PPPPHPP------PPPPPPPCGG- 126

  Fly   190 ISSPGAPTS-------------ASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSN 241
            |:..|.|..             .:.....|..:....:::.|...:.::.               
Human   127 IACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHL--------------- 176

  Fly   242 NNRTSPSKPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLEL 306
            |..:|||:  .|.||:..|.|                       |:.|.    |..|:.||.|||
Human   177 NQSSSPSQ--MFPWMRPQAAP-----------------------GRRRG----RQTYSRFQTLEL 212

  Fly   307 EKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKKGSDP 356
            |||:..:.|:|.:|:.|::..|:|:||||||||||||.|.:|:|.|...|
Human   213 EKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFP 262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cadNP_001260641.1 Homeodomain 293..348 CDD:459649 29/54 (54%)
HOXD8NP_062458.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..127 24/114 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..200 11/78 (14%)
Homeodomain 198..254 CDD:459649 30/59 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 255..290 3/8 (38%)

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