Protein Alignment cad and HOXD1

DIOPT Version :10

• Sequence 1: NP_001260641.1
• Gene: cad / 35341
• FlyBaseID: FBgn0000251
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_078777.1
• Gene: HOXD1 / 3231
• HGNCID: 5132
• Length: 328
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 73/297 - (24%)
• Similarity: 105/297 - (35%)
• Gaps: 92/297 - (30%)

  Fly    94 FVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSGGAPGAPQLNE-TNSSIGVGGAGGGGGVGG 157
            ||..:|.:|           |..|.|..::.:..|...|.|||..: |.......||......||
Human    50 FVSCLPLAA-----------ARPSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGG 103

  Fly   158 ATDGGPGSAP-----------------------------------PNHQQHIAEGLPSP-PITVS 186
            |..|..||.|                                   .....:.|.|.|.| |..:.
Human   104 ADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLK 168

  Fly   187 GSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPP 251
            .|....|||..:||.                        :|.|:     ..|||..:.. |:...
Human   169 ASADGHPGAFQTASP------------------------APGTY-----PKSVSPASGL-PAAFS 203

  Fly   252 YFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYRVVYTDFQRLELEKEYCTSRYI 316
            .|:|||       .:.:.|....|.:.       |........|..::..|..|||||:..::|:
Human   204 TFEWMK-------VKRNASKKGKLAEY-------GAASPSSAIRTNFSTKQLTELEKEFHFNKYL 254

  Fly   317 TIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNKKG 353
            |..|:.|:|..|.|::.||||||||||.|::|:.::|
Human   255 TRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREG 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cad	NP_001260641.1	Homeodomain	293..348	CDD:459649	25/54 (46%)
HOXD1	NP_078777.1	Antp-type hexapeptide	204..209		2/4 (50%)
		Homeodomain	233..286	CDD:459649	25/52 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..328